Progress of titanium dioxide nanostructures as carriers in sustained and controlled drug-release delivery system

doi:10.16085/j.issn.1000-6613.2017-2404

Abstract

Abstract: Due to its advantages of good biocompatibility, high mechanical strength, heat and corrosion resistance, the titanium dioxide nanostructures (TNSs) as drug carriers have been attracted more attention in the aspect of sustained and controlled drug-release delivery system. Referring to the recent literatures, single and functional TNSs as carriers for sustained and controlled drug-release are classified, and their preparation methods, structure characterization, drug loading methods, drug releasing mechanism et al. are briefly introduced. Moreover, the application of functionalized TNSs modification combined with external stimuli response in drug sustained and controlled drug-release system are analyzed in detail. The results showed the functional TNSs have the advantages of higher drug loading rate, more obvious sustained and controlled drug-release effect, and better biocompatibility. Functionalized TNSs modifications with external stimuli response are able to further enhance sustained and controlled drug-release effect. In addition, compared to the single and double stimuli-responsive, multiple stimuli-responsive has a better effect on the local target drug-release. Finally, the development trend of TNSs as sustained and controlled drug-release carriers and the current problems to solve in order to achieve the clinical application are discussed.

Key words: titanium dioxide nanostructures, drug delivery system, functional modification, sustained and controlled drug-release, stimuli-response

摘要： TiO₂纳米结构以其生物相容性好、机械强度高、耐热耐腐蚀等优点，在药物缓控释传递系统载体应用方面引起广泛关注。结合近几年研究报道，本文将单一和功能化TiO₂纳米结构作为药物缓控释载体进行分类，简述了制备方法、结构表征、载药方法、释药机理等，分析了功能化TiO₂纳米结构修饰结合外界刺激响应在药物缓控释系统的应用。结果表明，相比单一结构，功能化修饰后的TiO₂纳米结构具有载药率高、缓控释效果明显、生物相容性好等优点；功能化修饰结合外界刺激响应，进一步提升药物缓控释效果；而相比单一和双重刺激响应，多重刺激响应能够更好地实现局部靶向释药。最后预测该纳米结构作为药物缓控释传递系统载体的研究发展方向并指出目前实现临床应用所面临的问题。

关键词: TiO₂纳米结构, 药物传递系统, 功能修饰, 缓控释, 刺激响应

CLC Number:

O614.41

MENG Rongqian, LI Qiaoling, JIN Riya. Progress of titanium dioxide nanostructures as carriers in sustained and controlled drug-release delivery system[J]. Chemical Industry and Engineering Progress, 2018, 37(10): 3980-3987.

孟戎茜, 李巧玲, 晋日亚. TiO₂纳米结构作为载体在药物缓控释传递系统的应用[J]. 化工进展, 2018, 37(10): 3980-3987.

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