Progress of research on collagen self-assembly biological functional materials

doi:10.16085/j.issn.1000-6613.2017.06.034

Abstract

Abstract: Collagen self-assembled into highly ordered network structure in vitro,which helps to cell adhesion,proliferation,spreading,and migration. Collagen self-assembly biological functional materials have highly ordered structure characteristics,excellent mechanical properties,good biocompatibility,biodegradability,and low immunogenic idiosyncrasy. The assembly process of the four self-assembly technologies,which are template self-assembly technology,in situ self-assembly technology,directed self-assembly technology and induced self-assembly technology,is described. The status of research on those four self-assembly technologies is presented. The theory and characteristic of four self-assembly technologies is discussed. Then,the application of collagen self-assembly biological function materials as tissue replacement material,targeted drug delivery material,functional material of specific conduction of light,electricity,sound,is summarized. The development trend of collagen self-assembly biological function materials in regenerative medicine,gene therapy,drug design,tissue engineering,medical imaging,etc,is identified. Finally,the direction of future development of collagen self-assembly biological function material is proposed. Results show that the collagen self-assembly biological functional materials have broad application prospects in biomedical field.

Key words: protein, self-assembly, preparation, functional materials, biomedical engineering

摘要： 胶原蛋白在体外自组装形成高度有序的网状结构，有利于细胞的黏附、增殖、扩散和迁移，具有良好的生物相容性、优异的力学性能、可生物降解性和弱抗原性。本文首先介绍和分析了胶原蛋白自组装功能材料的4种组装方法，即模板自组装法、原位自组装法、定向自组装法和诱导自组装法和分析的研究现状；比较了4种自组装方法的组装原理和组装特点；然后总结了胶原蛋白自组装生物功能材料作为组织替代材料，靶向给药材料，光、电、声特异传导功能材料在再生医学、基因治疗、药物设计、组织工程、医学影像等领域的应用现状和发展趋势；最后指出了胶原蛋白自组装生物功能材料今后的研究方向，表明胶原蛋白自组装生物功能材料在生物医学领域具有广阔的应用前景。

关键词: 蛋白质, 自组装, 制备, 功能材料, 生物医学工程

CLC Number:

TQ93

WANG Ruirui, WANG Hongru. Progress of research on collagen self-assembly biological functional materials[J]. Chemical Industry and Engineering Progress, 2017, 36(06): 2215-2221.

王瑞瑞, 王鸿儒. 胶原蛋白自组装生物功能材料的研究进展[J]. 化工进展, 2017, 36(06): 2215-2221.

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