Abstract: Reactor is one of the main equipment of pharmaceutical chemical products and always appears in the form of stirring.This paper studied the influence of the design parameters of stirrer to the flow field of reactor,and improved the reactor structure based on the comparison result.The initial design of small pharmaceutical stirred tank was obtained using engineering design methods.The flow field in the stirred tank was analyzed using CFD method which were consistent with the report in the literature.Then,the design parameters of installation height and stirring speed of the stirrer were adjusted to obtain stimulation results.After that,the results were contrasted with the initial design.According to the design requirements such as mixing performance and input power of drive,the design was improved by optimizing the design parameters.

Key words: design of stirred tank, CFD, mixing performance, installation height, stirring speed

摘要： 反应釜是制药化工产品生产的主要设备之一，常以搅拌的形式出现。本文研究了搅拌器相关设计参数对反应釜内流场的影响，并以此为依据改进反应釜结构。首先通过工程设计方法得到小型制药搅拌釜的初始设计方案，利用CFD技术对搅拌釜内的流场进行数值模拟研究，所得结果与文献中的结果基本一致。然后调整反应釜搅拌器的安装高度与搅拌转速等设计参数，与初始设计方案进行模拟结果对比分析，根据混合效果与驱动输入功率等设计要求，修改设计参数得到更优的设计方案。

关键词: 搅拌釜设计, 计算流体力学, 混合效果, 安装高度, 搅拌转速