化工进展 ›› 2019, Vol. 38 ›› Issue (07): 3243-3252.DOI: 10.16085/j.issn.1000-6613.2018-1829
收稿日期:
2018-09-10
出版日期:
2019-07-05
发布日期:
2019-07-05
通讯作者:
邢杨,李法云
作者简介:
狄玲(1984—),女,博士,讲师,研究方向为有机合成方法学。E-mail:<email>diling@lnpu.edu.cn</email>。
基金资助:
Ling DI(),Yang XING(),Guangkuo DAI,Yu ZHENG,Qiang XU,Xiaohe YU,Fayun LI()
Received:
2018-09-10
Online:
2019-07-05
Published:
2019-07-05
Contact:
Yang XING,Fayun LI
摘要:
氟烷基化反应作为有机氟化学领域的重要研究课题,能够直接将含氟基团引入有机分子,并通过含氟基团的“氟效应”改善有机分子的理化性质。以有机硼酸为代表的有机硼试剂具有对水及空气不敏感、反应活性高、官能团兼容性好、低毒等优点。近年来,诸多基于有机硼试剂的脱硼氟烷基化反应被报道。本文首先依据氟烷基化试剂在反应过程中体现的电子性质,从亲核型氟烷基化、亲电氟烷基化及自由基氟烷基化3个方面,对目前脱硼氟烷基化反应所涉及的氟试剂、催化剂、溶剂、气氛条件、反应收率、底物普适性及反应机理进行了归纳和总结;之后对近几年来新兴的光催化脱硼氟烷基化反应进行了单独介绍;最后从绿色化学角度对脱硼氟烷基化反应在光催化领域的发展趋势做了总结和展望。指出未来脱硼氟烷基化反应将沿着探索温和、高效、环境友好催化体系的趋势,发展更具环境、经济及社会效益的合成方法。
中图分类号:
狄玲, 邢杨, 戴光阔, 郑宇, 徐强, 于潇贺, 李法云. 脱硼氟烷基化反应研究进展[J]. 化工进展, 2019, 38(07): 3243-3252.
Ling DI, Yang XING, Guangkuo DAI, Yu ZHENG, Qiang XU, Xiaohe YU, Fayun LI. Research progress on protodeboronized fluoroalkylations[J]. Chemical Industry and Engineering Progress, 2019, 38(07): 3243-3252.
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