分子识别型智能微囊的制备及其控制释放特性

doi:10.16085/j.issn.1000-6613.2015.01.032

化工进展 ›› 2015, Vol. 34 ›› Issue (1): 183-187,244.DOI: 10.16085/j.issn.1000-6613.2015.01.032

分子识别型智能微囊的制备及其控制释放特性

杨超, 谢锐, 巨晓洁, 汪伟, 褚良银

四川大学化学工程学院, 四川成都 610065

收稿日期:2014-04-28 修回日期:2014-05-28 出版日期:2015-01-05 发布日期:2015-01-05
通讯作者: 谢锐,副教授,博士生导师,主要从事智能膜材料、微流控技术方面的研究。E-mail xierui@scu.edu.cn。
作者简介:杨超(1988-),男,硕士研究生,研究分子识别智能微囊材料。
基金资助:
教育部新世纪优秀人才支持计划(NCET-11-0352)及四川大学优秀青年学者科研基金(2011SCU04A15)项目。

Fabrication and controlled-release characteristics of molecular-recognizable smart microcapsules

Yang Chao, Xie Rui, Ju Xiaojie, Wang Wei, Chu Liangyin

School of Chemical Engineering, Sichuan University, Chengdu 610065, Sichuan, China

Received:2014-04-28 Revised:2014-05-28 Online:2015-01-05 Published:2015-01-05

摘要/Abstract

摘要： 采用微流控乳化和紫外光照引发制备聚(N-异丙基丙烯酰胺-共聚-丙烯酸)微囊,然后通过缩合反应将氨基化β-环糊精(ECD)引入微囊成功制备得到聚(N-异丙基丙烯酰胺-共聚-丙烯酸/氨基化β-环糊精)(PNA-ECD)微囊。PNA-ECD微囊具有明显的核壳型结构和良好的单分散性。微囊的平均直径为470μm,CV值为2.98%。PNA-ECD微囊在识别模型芳环分子8-苯胺-1-萘磺酸铵盐(ANS)后能等温收缩从而实现对内载药物的控制释放。32℃时,微囊内部的模型药物异硫氰酸荧光素标记葡聚糖(FITC-dextran)在纯水中无明显释放,而在加入2.0mmol/L ANS溶液16min后,微囊内部约70%的FITC-dextran释放到微囊外部。研究结果对制备单分散分子识别型智能微囊及研究其控制释放特性提供有价值的理论指导和实验基础。

关键词: 微囊, 分子识别, 控制释放, 微流体学, 乳液, 传质, 微囊, 分子识别, 控制释放, 微流体学, 乳液, 传质

Abstract: Poly(N-isopropylacrylamide-co-acrylic acid/aminated β-cyclodextrin) (PNA-ECD) microcapsules were fabricated by the condensation reaction between aminated β-cyclodextrin and poly(N-isopropylacrylamide-co-acrylic acid) microcapsules. The poly(N-isopropylacrylamide-co- acrylic acid) microcapsules were prepared by initiating polymerization of multiple emulsion containing N-isopropylacrylamide and acrylic acid, which was generated by microfluidic emulsification. The PNA-ECD microcapsules showed core-shell structure and satisfactory monodispersity. Average outer diameter of microcapsules was 470 μm, and CV value was 2.98%. By recognizing model molecules 8-anilino-1-naphthalenesulfonic acid ammonium salt (ANS), the PNA-ECD microcapsules isothermally shrunk and controllably released the encapsulated model drug molecule fluorescein isothiocyanate labeled dextran (FITC-dextran). At 32℃, there was no obvious drug release for the PNA-ECD microcapsules in pure water, while about 70% of the encapsulated FITC-dextran was released from the microcapsules after adding ANS solution (2.0mmol/L) for 16min. The results provide valuable guidance for fabrication of monodisperse molecular-recognizable microcapsules and studying their molecular-recognizable characteristics.

Key words: microcapsules, molecular recognition, controlled release, microfluidics, emulsions, mass transfer, microcapsules, molecular recognition, controlled release, microfluidics, emulsions, mass transfer

中图分类号:

TQ316

杨超, 谢锐, 巨晓洁, 汪伟, 褚良银. 分子识别型智能微囊的制备及其控制释放特性[J]. 化工进展, 2015, 34(1): 183-187,244.

Yang Chao, Xie Rui, Ju Xiaojie, Wang Wei, Chu Liangyin. Fabrication and controlled-release characteristics of molecular-recognizable smart microcapsules[J]. Chemical Industry and Engineering Progree, 2015, 34(1): 183-187,244.

参考文献

[1] Chu L Y,Park S H,Yamaguchi T,et al. Preparation of micron-sized monodispersed thermoresponsive core-shell microcapsules[J]. Langmuir,2002,18(5):1856-1864.

[2] Choi C H,Jung J H,Kim D W,et al. Novel one-pot route to monodisperse thermosensitive hollow microcapsules in a microfluidic system[J]. Lab on a Chip,2008,8(9):1544-1551.

[3] Wang A,Tao C,Cui Y,et al. Assembly of environmental sensitive microcapsules of PNIPAAm and alginate acid and their application in drug release[J]. Journal of Colloid and Interface Science,2009,332(2):271-279.

[4] Liu L,Yang J P,Ju X J,et al. Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs[J]. Soft Matter,2011,7(10):4821-4827.

[5] Li C,Luo G F,Wang H Y,et al. Host-guest assembly of pH-responsive degradable microcapsules with controlled drug release behavior[J]. The Journal of Physical Chemistry C,2011,115(36):17651-17659.

[6] 张豪,褚良银,胡林. PHEMA多孔微球和微囊的制备及生物医药应用进展[J]. 化工进展,2008,27(2):196-205.

[7] Zebli B,Susha A S,Sukhorukov G B,et al. Magnetic targeting and cellular uptake of polymer microcapsules simultaneously functionalized with magnetic and luminescent nanocrystals[J]. Langmuir,2005,21(10):4262-4265.

[8] 杨文川,褚良银,庞雪芹,等. 磁性温度感应微囊膜的制备与表征[J]. 化工进展,2008,27(1):120-124.

[9] Guo H,Zhao X,Wang J. Synthesis of functional microcapsules containing suspensions responsive to electric fields[J]. Journal of Colloid and Interface Science,2005,284(2):646-651.

[10] Bogdanowicz K A,Tylkowski B,Giamberini M. Preparation and characterization of light-sensitive microcapsules based on a liquid crystalline polyester[J]. Langmuir,2013,29(5):1601-1608.

[11] Xiao W,Chen W H,Zhang J,et al. Design of a photoswitchable hollow microcapsular drug delivery system by using a supramolecular drug-loading approach[J]. The Journal of Physical Chemistry B,2011,115(46):13796-13802.

[12] Pi S W,Ju X J,Wu H G,et al. Smart responsive microcapsules capable of recognizing heavy metal ions[J]. Journal of Colloid and Interface Science,2010,349(2):512-518.

[13] Chu L Y,Liang Y J,Chen W M,et al. Preparation of glucose-sensitive microcapsules with a porous membrane and functional gates[J]. Colloids and Surfaces B:Biointerfaces,2004,37(1-2):9-14.

[14] Chu L Y,Yamaguchi T,Nakao S I. A molecular-recognition microcapsule for environmental stimuli-responsive controlled release[J]. Advanced Materials,2002,14(5):386-389.

[15] Liu Z,Liu L,Ju X J,et al. K⁺-recognition capsules with squirting release mechanisms[J]. Chemical Communications,2011,47(45):12283.

[16] Zhang M J,Wang W,Xie R,et al. Microfluidic fabrication of monodisperse microcapsules for glucose-response at physiological temperature[J]. Soft Matter,2013,9(16):4150-4159.

[17] Lu S W,An L,Qing X X. Water solubility enhancement of phthalates by cetyltrimethylammonium bromide and α-cyclodextrin[J]. Industrial & Engineering Chemistry Research,2003,42(5):949-955.

[18] 张京,董洁,李凡. 用于多环芳烃裂解催化剂的研究进展[J]. 化工进展,2011,30(s1):129-133.

[19] 蒋平平,张书源,冷炎,等. 催化合成环保增塑剂的研究及其应用进展[J]. 化工进展,2012,31(5):953-964.

[20] Guo Y R,Liang X,Wang Y Y,et al. Cyclodextrin-based molecularly imprinted polymers for the efficient recognition of pyrethroids in aqueous media[J]. Journal of Applied Polymer Science,2013,128(6):4014-4022.

[21] 黄怡,范晓东. 碱性水溶液中β-环糊精的选择性磺酰化[J]. 西北大学学报:自然科学版,2003,33(1):41-44.

[22] Bonomo R P,Cucinotta V,Allessandro F D,et al. Coordination properties of 6-deoxy-6-[1-(2-amino)ethylamino]-/3-cyclodextrin and the ability of its copper(Ⅱ) complex to recognize and separate amino acid enantiomeric pairs[J]. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry,1993,15(2):167-180.

[23] Li L,Guo X H,Fu L,et al. Complexation behavior of α-,β-,and γ-cyclodextrin in modulating and constructing polymer networks[J]. Langmuir,2008,24(15):8290-8296.

[24] Guo X H,Abdala A A,May B L,et al. Novel associative polymer networks based on cyclodextrin inclusion compounds[J]. Macromolecules,2005,38(7):3037-3040.

[25] Li L,Guo X H,Wang J,et al. Polymer networks assembled by host-guest Inclusion between adamantyl and β-cyclodextrin substituents on poly(acrylic acid) in aqueous solution[J]. Macromolecules,2008,41(22):8677-8681.

分子识别型智能微囊的制备及其控制释放特性

Fabrication and controlled-release characteristics of molecular-recognizable smart microcapsules

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	邵博识, 谭宏博. 锯齿波纹板对挥发性有机物低温脱除过程强化模拟分析[J]. 化工进展, 2023, 42(S1): 84-93.
[2]	盛维武, 程永攀, 陈强, 李小婷, 魏嘉, 李琳鸽, 陈险峰. 微气泡和微液滴双强化脱硫反应器操作分析[J]. 化工进展, 2023, 42(S1): 142-147.
[3]	黄益平, 李婷, 郑龙云, 戚傲, 陈政霖, 史天昊, 张新宇, 郭凯, 胡猛, 倪泽雨, 刘辉, 夏苗, 主凯, 刘春江. 三级环流反应器中气液流动与传质规律[J]. 化工进展, 2023, 42(S1): 175-188.
[4]	杨寒月, 孔令真, 陈家庆, 孙欢, 宋家恺, 王思诚, 孔标. 微气泡型下向流管式气液接触器脱碳性能[J]. 化工进展, 2023, 42(S1): 197-204.
[5]	陈匡胤, 李蕊兰, 童杨, 沈建华. 质子交换膜燃料电池气体扩散层结构与设计研究进展[J]. 化工进展, 2023, 42(S1): 246-259.
[6]	王琦, 寇丽红, 王冠宇, 王吉坤, 刘敏, 李兰廷, 王昊. 焦化废水生物出水中可溶解性有机物的分子识别[J]. 化工进展, 2023, 42(9): 4984-4993.
[7]	李洞, 王倩倩, 张亮, 李俊, 付乾, 朱恂, 廖强. 非水系纳米流体热再生液流电池串联堆性能特性[J]. 化工进展, 2023, 42(8): 4238-4246.
[8]	赵健, 卓泽文, 董航, 高文健. 含蜡原油及其乳状液体系微观结构观测的新方法[J]. 化工进展, 2023, 42(8): 4372-4384.
[9]	吴亚, 赵丹, 方荣苗, 李婧瑶, 常娜娜, 杜春保, 王文珍, 史俊. 用于复杂原油乳液的高效破乳剂开发及应用研究进展[J]. 化工进展, 2023, 42(8): 4398-4413.
[10]	李瑞东, 黄辉, 同国虎, 王跃社. 原油精馏塔中铵盐吸湿特性及其腐蚀行为[J]. 化工进展, 2023, 42(6): 2809-2818.
[11]	章凯, 金捍宇, 刘思宇, 王帅. 鼓泡流态化气泡间相互作用下相间传质过程的模拟[J]. 化工进展, 2023, 42(6): 2828-2835.
[12]	陶梦琦, 刘美红, 康宇驰. 基于micro-PIV的微通道内流体绕流单微圆柱和并联双微圆柱流场特性[J]. 化工进展, 2023, 42(6): 2836-2844.
[13]	杨扬, 孙志高, 李翠敏, 李娟, 黄海峰. 静态条件下表面活性剂OP-13促进HCFC-141b水合物生成[J]. 化工进展, 2023, 42(6): 2854-2859.
[14]	马哲杰, 张文励, 赵炫凯, 李平. PEMFC阴极催化层氧传质阻力影响的研究进展[J]. 化工进展, 2023, 42(6): 2860-2873.
[15]	陈伟良, 高鑫, 李洪, 李鑫钢. 泡沫碳化硅波纹规整填料骨架结构对其传质性能的影响机理[J]. 化工进展, 2023, 42(5): 2289-2297.