化工进展 ›› 2020, Vol. 39 ›› Issue (4): 1447-1457.DOI: 10.16085/j.issn.1000-6613.2019-1262
杜晓芳(),李兆周(),陈秀金,王耀,高红丽,李道敏,任国艳,吕璞
收稿日期:
2019-08-05
出版日期:
2020-04-05
发布日期:
2020-04-28
通讯作者:
李兆周
作者简介:
杜晓芳(1996—),女,硕士研究生,研究方向为食品安全检测与评价。E-mail:基金资助:
Xiaofang DU(),Zhaozhou LI(),Xiujin CHEN,Yao WANG,Hongli GAO,Daomin LI,Guoyan REN,Pu LÜ
Received:
2019-08-05
Online:
2020-04-05
Published:
2020-04-28
Contact:
Zhaozhou LI
摘要:
随着人工合成的喹诺酮类抗菌药在动物性食品中残留和环境中蓄积日趋严重,其安全和健康风险促使开发快速且灵敏的检测方法已迫在眉睫。本文介绍了喹诺酮类药物印迹仿生抗体的制备方法,包括本体聚合法、悬浮聚合法、原位聚合法、沉淀聚合法及表面分子印迹法;总结了其作为萃取介质及传感识别元件在肉、蛋、奶、土壤、水体及生物样品检测中的应用;结合分子印迹技术制备工艺及应用的最新研究进展,讨论了该类仿生抗体在制备及识别过程中所面临的印迹容量和效应低、识别模式和传质机理研究不透彻等问题;提出了相应的解决方案,包括新型功能单体的优选及合成、高性能识别模式和制备方法的构建及开发等,为新型印迹仿生抗体的研制及应用提供了参考思路和技术途径。
中图分类号:
杜晓芳,李兆周,陈秀金,王耀,高红丽,李道敏,任国艳,吕璞. 喹诺酮类药物印迹仿生抗体的研制及应用进展[J]. 化工进展, 2020, 39(4): 1447-1457.
Xiaofang DU,Zhaozhou LI,Xiujin CHEN,Yao WANG,Hongli GAO,Daomin LI,Guoyan REN,Pu LÜ. Development and application progress of quinolone imprinted biomimetic antibody[J]. Chemical Industry and Engineering Progress, 2020, 39(4): 1447-1457.
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