关键词: 分子印迹, 凝胶, N-异丙基丙烯酰胺, 聚合物, 选择性

Abstract: Molecular imprinting technology has been developed rapidly in recent years and applied in various fields，including separation engineering，chemical sensors and analogy enzyme catalysis，due to its high selectivity，specific recognition and so on. However，a little attention has been paid to molecularly imprinted hydrogels. Temperature-sensitive molecularly imprinted hydrogels，obtained by combining molecular imprinting technique with temperature-sensitive hydrogels，provide both the specific identification properties and stimuli-responsiveness to the environment temperature changes，which means that the specific recognition of such hydrogels to the template molecules changes with temperature variation. This paper is aimed to not only review the specific identification principle and preparation approaches of temperature-sensitive molecularly imprinted hydrogels，but also to highlight the application of temperature-sensitive molecularly imprinted hydrogels in metal-ion，organic molecules and protein imprinting. In this review，the possible development of temperature-sensitive molecularly imprinted hydrogels is prospected，which will show enormous potential applications in many fields，such as material separation and drug controlled release system.

Key words: molecular imprinting, gels, N-isopropylacrylamide, polymers, selectivity