关键词: (2S, 3R)-2-羟基-3-氨基-4-苯基丁酸, 氨肽酶, 抑制剂, 合成方法

Abstract: (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA) is a key intermediate for preparing aminopeptidase N inhibitors，such as Bestatin，Phebestin and Probestin. Different synthetic routes，such as amino acid protocols ( D-phenylalanine，L-aspartic acid，malate diester)，organometallic methods (bifunctional aluminum complex)，acetophenone methods，enzyme routes (lipase and whole-cell enzyme)，and other approaches for preparing AHPBA are reviewed and analyzed. By comparison，organometallic catalysis，enzyme routes and acetophenone methods are superior in low-cost，mild condition，simple procedure with potential application for commercialization. The future development of this specific area will be focused on optimization and improvement of the reported routes.

Key words: (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid(AHPBA), aminopeptidase, inhibitor, synthetic method