关键词: 时间温度指示剂, 类型, 制备方法, 选择

Abstract: Time-temperature indicator (TTI) is a novel means to monitor the security of some host products such as food and vaccines，which can record the course and reflect the remaining shelf life of these host products by time-temperature accumulative effects of physical and chemical change，thus solving the problem of shelf life is not a real-time monitoring indicator of host product quality. The latest advances in TTIs were reviewed；their kinds，working principles，preparations and applications were expounded. Kinds of TTIs were divided into diffuse type，polymerization reaction type and enzyme reaction type by their indicating principle. The diffusion-type indicator is carried by the flow of molten material directions，polymerization type is for the carbon-carbon triple bond polymerization reaction and the molecular conformation change induced color change to play the time-temperature indicator effects，enzyme reaction type indicator is through the starch with enzyme color reaction to time temperature indicator. Preparation methods are divided into physical，chemical and physical chemical method. Applications choice is also discussed.

Key words: time-temperature indicator, types, preparation, selection