关键词: 2, 4-二乙氧基-5-硝基苯胺, N-(2, 4-二乙氧基-5-硝基苯基)苯甲酰胺, N-(5-氨基-2, 4-二乙氧基苯基)苯甲酰胺, 酰化反应, 还原反应, 2,4-二乙氧基-5-硝基苯胺, N-(2,4-二乙氧基-5-硝基苯基)苯甲酰胺, N-(5-氨基-2,4-二乙氧基苯基)苯甲酰胺, 酰化反应, 还原反应

Abstract: Through acylation and reduction reaction，N-(5-amino-2,4-diethoxyphenyl) benzamide（DEBAB）was synthesized from 2,4-diethoxy-5-nitroaniline（DEANB）and the experimental conditions，such as materials ratio，reaction temperature and reaction time，were investigated. Proper experimental conditions for acylation reaction were found as：n(DEANB)∶n(benzoyl chloride)= 1∶1.25，H₂O and CH₃OH as solvent，K₂CO₃ as deacid reagent reaction temperature 0 ℃，reaction time 1 h，the yield of N-(2,4-diethoxy-5-nitrophenyl) benzamide（DEBNB）was 90.95% based on DEANB and the purity was 98.35% as determined by HPLC；proper reduction reaction conditions were found as：n(DEBNB)∶n(Fe)= 1∶4，H₂O and C₂H₅OH as solvent，reaction temperature 80 ℃，reaction time 5 h，pressure of hydrogen 1.5 MPa，the yield of DEDAB was 89.93% based on DEDNB and the purity was 98.96% as determined by HPLC. The molecular structures of product and its intermediates were identified by ¹H-NMR，MS and FT-IR.

Key words: 2,4-diethoxy-5-nitroaniline（DEANB）, N-(2,4-diethoxy-5-nitrophenyl) benzamide（DEBNB）, N-(5-amino-2,4-diethoxyphenyl) benzamide（DEBAB）, acylation reaction, reduction reaction, 2,4-diethoxy-5-nitroaniline（DEANB）, N-(2,4-diethoxy-5-nitrophenyl) benzamide（DEBNB）, N-(5-amino-2,4-diethoxyphenyl) benzamide（DEBAB）, acylation reaction, reduction reaction