Abstract: The product in the production of γ-decalactone by biological pathway has obvious toxicity to the growth of Yarrowia lypolitica.Resin AB-8 was added to adsorb converted product to reduce the toxicity on Yarrowia lypolitica.The optimum conditions were castor oil 25g/L，7.5% AB-8，pH 7.5. The maximal specific γ -decalactone formation rate increased by 36% and decreased slowly after it reached a maximum，leading to better product accumulation. The total product concentration reached 2.17g/L after 56h. As a result，addition of resin not only increased the production but also separated the product.