表没食子儿茶素没食子酸酯的纳米化封装及应用

doi:10.16085/j.issn.1000-6613.2024-1973

化工进展 ›› 2025, Vol. 44 ›› Issue (12): 7152-7164.DOI: 10.16085/j.issn.1000-6613.2024-1973

• 生物与医药化工 • 上一篇

表没食子儿茶素没食子酸酯的纳米化封装及应用

陈晓真¹(), 苏艳蕾¹, 陆兴蕾¹, 冯杰², 周凯迪¹, 关欣¹, 蓝丽红¹, 蓝平¹(), 何日梅²()

^1.广西民族大学化学化工学院，广西多糖材料与改性重点实验室，广西南宁 530000
^2.广西壮族自治区计量检测研究院，广西南宁 530200

收稿日期:2024-12-02 修回日期:2025-02-25 出版日期:2025-12-25 发布日期:2026-01-06
通讯作者: 蓝平,何日梅
作者简介:陈晓真（1998—），女，硕士研究生，研究方向为生物质材料。E-mail：chenxz 202111 @163.com。
基金资助:
广西生物多糖分离纯化及改性研究平台建设(桂科ZY18076005);广西重点研发计划(桂科AB21220054);广西区市场监管局科技计划(GXSJKJ 2022-8);广西壮族自治区级大学生创新创业训练计划(S202310608237);广西壮族自治区级大学生创新创业训练计划(S202310608144)

Nano encapsulation and application of epigallocatechin gallate

CHEN Xiaozhen¹(), SU Yanlei¹, LU Xinglei¹, FENG Jie², ZHOU Kaidi¹, GUAN Xin¹, LAN Lihong¹, LAN Ping¹(), HE Rimei²()

^1.Key Laboratory of Polysaccharide Materials and Modification, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530000, Guangxi, China
^2.Guangxi Zhuang Autonomous Region Institute of Metrology and Test, Nanning 530200, Guangxi, China

Received:2024-12-02 Revised:2025-02-25 Online:2025-12-25 Published:2026-01-06
Contact: LAN Ping, HE Rimei

摘要/Abstract

摘要：

利用木薯淀粉为原料，采用超声微波辅助醇沉法制备表没食子儿茶素没食子酸酯（EGCG）纳米淀粉颗粒（EGCG-SNPs）。介绍了EGCG的同步纳米化封装方法，并使用傅里叶变换红外光谱（FTIR）、场发射扫描电子显微镜（SEM）、X射线粉末衍射（XRD）、热重分析（TGA）和激光粒度仪等技术对EGCG-SNPs的物理化学性质进行了分析。研究结果表明，EGCG-SNPs具有均匀的粒径[(139.10±18.53)nm]和球形结构，表面具有轮纹。XRD分析显示其晶型由木薯淀粉的A形结构转变为V形结构，结晶度显著降低，热稳定性得到改善。FTIR分析进一步表明EGCG与淀粉之间的氢键作用增强，提升了纳米颗粒的结构稳定性。EGCG-SNPs具有较高的载药量[（378.05±3.04）mg/g]和包埋率（50.02%±2.22%），并在DPPH和ABTS自由基清除实验中表现出显著的抗氧化活性。药物释放实验表明，EGCG-SNPs在模拟消化环境中表现出较好的缓释性能。综上所述，EGCG-SNPs不仅具有良好的包埋效果和缓释性能，还表现出稳定的抗氧化活性，相比游离EGCG，EGCG-SNPs药效显著提高。本文为EGCG在药物传递、癌症治疗及相关疾病防治中的应用提供了新的思路。

关键词: 纳米技术, 表没食子儿茶素没食子酸酯, 同步封装, 药物缓释, 淀粉

Abstract:

This study utilized cassava starch as the raw material and employed an ultrasound-microwave-assisted alcohol precipitation method to prepare epigallocatechin gallate (EGCG) nanostarch particles (EGCG-SNPs). The method for the simultaneous nanofication and encapsulation of EGCG was introduced, and the physicochemical properties of EGCG-SNPs were thoroughly characterized using Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (SEM), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and laser particle size analysis. The results showed that the EGCG-SNPs exhibited a uniform particle size [(139.10±18.53)nm] and spherical morphology with a wrinkled surface. XRD analysis revealed that the crystalline structure of EGCG-SNPs shifted from the typical A-shape crystalline structure of native cassava starch to a weaker V-shape crystalline structure with a significant reduction in crystallinity and improved thermal stability. FTIR analysis further indicated that the hydrogen bonding interaction between EGCG and starch was enhanced, thereby improving the structural stability of the nanoparticles. The EGCG-SNPs demonstrated a high drug loading capacity [(378.05±3.04)mg/g] and encapsulation efficiency (50.02%±2.22%) and exhibited significant antioxidant activity in DPPH and ABTS free radical scavenging assays. Drug release experiments found that EGCG-SNPs exhibited sustained release behavior in simulated digestive environments. In conclusion, EGCG-SNPs not only exhibited excellent encapsulation efficiency and sustained release properties but also demonstrated stable antioxidant activity, significantly enhancing the therapeutic effect compared to free EGCG. This study provided new insights into the application of EGCG in drug delivery, cancer therapy and the prevention of related diseases.

Key words: nanotechnology, epigallocatechin gallate, simultaneous encapsulation, drug release, starch

中图分类号:

TQ07

陈晓真, 苏艳蕾, 陆兴蕾, 冯杰, 周凯迪, 关欣, 蓝丽红, 蓝平, 何日梅. 表没食子儿茶素没食子酸酯的纳米化封装及应用[J]. 化工进展, 2025, 44(12): 7152-7164.

CHEN Xiaozhen, SU Yanlei, LU Xinglei, FENG Jie, ZHOU Kaidi, GUAN Xin, LAN Lihong, LAN Ping, HE Rimei. Nano encapsulation and application of epigallocatechin gallate[J]. Chemical Industry and Engineering Progress, 2025, 44(12): 7152-7164.

图/表 12

图1 EGCG-SNPs纳米淀粉颗粒的形成机理示意图

图2 EGCG-3SNPs的EE与LC随EGCG浓度的变化

图3 1EGCG-SNPs的EE与LC随淀粉浓度的变化

表1 粒径与zeta电位结果

样品	粒径/nm	分散系数/%	zeta电位/mV
SNPs	64.62±2.25	0.45±0.04	-5.46±0.37
EGCG-SNPs	139.10±18.53	0.22±0.03	-11.63±0.25

图4 EGCG、原木薯淀粉、SNPs、EGCG-SNPs淀粉纳米颗粒的XRD图谱

图5 原木薯淀粉、SNPs、EGCG-SNPs的SEM照片

图6 SNPs和EGCG-SNPs的TGA和DTG曲线

图7 原木薯淀粉、SNPs、EGCG-SNPs淀粉纳米颗粒的FTIR图谱

图8 EGCG-SNPs和SNPs的DPPH和ABTS自由基清除效果

图9 EGCG和EGCG-SNPs的体外消化缓释模拟曲线

图10 EGCG-SNPs释药动力学拟合曲线

表2 药动学拟合参数

样品名称	模型	回归方程	R²
EGCG-SNPs胰液	零级药动学	y=3.68x +1.54	0.9847
	一级药动学	y=-18936.21(1-e^2.13^x )	0.9696
	Higuchi药动学	y=15.36x^1/2-13.87	0.9358
	Ritger-peppas药动学	y=4.531x^0.93	0.9814
EGCG-SNPs胃液	零级药动学	y=4.00 x-6.14	0.9906
	一级药动学	y=18498.17(1-e^-0.000064^x )	0.3161
	Higuchi药动学	y=13.17x^1/2-16.78	0.9960
	Ritger-peppas药动学	y=0.50x^2.06	0.8302

参考文献 45

[1]	Marta WŁODARCZYK, CIEBIERA Michał, NOWICKA Grażyna, et al. Epigallocatechin gallate for the treatment of benign and malignant gynecological diseases-focus on epigenetic mechanisms[J]. Nutrients, 2024, 16(4): 559.
[2]	侯改霞. 表没食子儿茶素没食子酸酯(EGCG)的生物学功能及其在运动医学领域的研究展望[J]. 河南大学学报(医学版), 2024, 43(1): 12-18.
	HOU Gaixia. Biological functions of epigallocatechin-3-gallate (EGCG) and its research perspectives in sports medicine[J]. Journal of Henan University (Medical Science), 2024, 43(1): 12-18.
[3]	JIA Zi, MAISHI Nako, TAKEKAWA Hideki, et al. Targeting tumor endothelial cells by EGCG using specific liposome delivery system inhibits vascular inflammation and thrombosis[J]. Cancer Medicine, 2024, 13(23): e70462.
[4]	MAO Shuifang, ZENG Yujun, REN Yanming, et al. EGCG induced the formation of protein nanofibrils hydrogels with enhanced anti-bacterial activity[J]. Food Hydrocolloids, 2024, 157: 110408.
[5]	Tanushree DAS, MONDAL Sanchaita, Sujata DAS, et al. Enhanced anticancer activity of (-)-epigallocatechin-3-gallate (EGCG) encapsulated NPs toward colon cancer cell lines[J]. Free Radical Research, 2024, 58(10): 565-582.
[6]	CHEN Ying, LIU Zhonghua, GONG Yushun. Neuron-immunity communication: Mechanism of neuroprotective effects in EGCG[J]. Critical Reviews in Food Science and Nutrition, 2024, 64(25): 9333-9352.
[7]	WANG Yingqi, LI Qingsheng, ZHENG Xinqiang, et al. Antiviral effects of green tea EGCG and its potential application against COVID-19[J]. Molecules, 2021, 26(13): 3962.
[8]	GUAN Yingling, ZHU Hengxing, LIN Minghao, et al. Preparation and stability evaluation of flexible nanoliposomes co-encapsulated with black wolfberry anthocyanins and EGCG[J]. LWT, 2025, 217: 117402.
[9]	KORIN Ali, GOUDA Mostafa M, YOUSSEF Mahmoud, et al. Whey protein sodium-caseinate as a deliverable vector for EGCG: in vitro optimization of its bioaccessibility, bioavailability, and bioactivity mode of actions[J]. Molecules, 2024, 29(11): 2588.
[10]	PANDEY Pratibha, VERMA Meenakshi, LAKHANPAL Sorabh, et al. An updated review summarizing the anticancer potential of poly(lactic-co-glycolic acid) (PLGA) based curcumin, epigallocatechin gallate, and resveratrol nanocarriers[J]. Biopolymers, 2025, 116(1): e23637.
[11]	SILVA GOMES Beatriz DA, CLÁUDIA PAIVA-SANTOS Ana, VEIGA Francisco, et al. Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers[J]. Advanced Drug Delivery Reviews, 2024, 207: 115197.
[12]	LI Danhui, MARTINI Nataly, WU Zimei, et al. Niosomal nanocarriers for enhanced dermal delivery of epigallocatechin gallate for protection against oxidative stress of the skin[J]. Pharmaceutics, 2022, 14(4): 726.
[13]	易聪华, 徐青荷, 王淼, 等. pH敏感性生物基纳米载药粒子的研究进展[J]. 化工进展, 2021, 40(6): 3411-3420.
	YI Conghua, XU Qinghe, WANG Miao, et al. Research progress of pH-sensitive biopolymer nanocarriers[J]. Chemical Industry and Engineering Progress, 2021, 40(6): 3411-3420.
[14]	ZHANG Guojuan, ZHANG Jianfang. Enhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: Characterization and in vivo investigation on nephrotic syndrome rats[J]. Drug Design, Development and Therapy, 2018, 12: 2509-2518.
[15]	林爽. 具有氧化还原响应的EGCG/Cys交联载药纳米颗粒的制备和性能研究[D]. 成都: 西南交通大学, 2019.
	LIN Shuang. Preparation and performance study of EGCG/Cys cross-linked drug-loaded nanoparticles with redox response[D]. Chengdu: Southwest Jiaotong University, 2019.
[16]	XU Shibo, CHANG Linna, ZHAO Xingjun, et al. Preparation of epigallocatechin gallate decorated Au-Ag nano-heterostructures as NIR-sensitive nano-enzymes for the treatment of osteoarthritis through mitochondrial repair and cartilage protection[J]. Acta Biomaterialia, 2022, 144: 168-182.
[17]	GAO Pengfei, ZUO Yangpeng, YANG Yulu, et al. Multifunctional photothermal PB@EGCG-Sr nanocoating design on titanium surface: To achieve short-term rapid osseointegration and on-demand photothermal long-term osteogenesis[J]. Chemical Engineering Journal, 2023, 474: 145608.
[18]	LE Jingqing, YANG Fang, YIN Mengdie, et al. Biomimetic polyphenol-coated nanoparticles by co-assembly of mTOR inhibitor and photosensitizer for synergistic chemo-photothermal therapy[J]. Colloids and Surfaces B: Biointerfaces, 2022, 209: 112177.
[19]	WU Bingbing, SHAO Yuyan, ZHAO Wei, et al. Dual functions of epigallocatechin gallate surface-modified Au nanorods@selenium composites for near-infrared-II light-responsive synergistic antibacterial therapy[J]. Journal of Biomaterials Applications, 2022, 36(10): 1812-1825.
[20]	张胜梦, 陈雨晴, 游益, 等. 多糖-蛋白质纳米载体研究进展[J]. 河南工业大学学报(自然科学版), 2024, 45(6): 137-149.
	ZHANG Shengmeng, CHEN Yuqing, YOU Yi, et al. Research progress in polysaccharide-protein nanocarriers[J]. Journal of Henan University of Technology (Natural Science Edition), 2024, 45(6): 137-149.
[21]	ABDI Gholamreza, JAIN Mukul, PATIL Nil, et al. Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications[J]. Frontiers in Materials, 2024, 11: 1296399.
[22]	MEI Shijuan, ROOPASHREE R, ALTALBAWY Farag M A, et al. Synthesis, characterization, and applications of starch-based nano drug delivery systems for breast cancer therapy: A review[J]. International Journal of Biological Macromolecules, 2024, 280: 136058.
[23]	BHAVYA E P, RAMAN Maya. Comprehensive review on synthesis of nano starch and its applications in food packaging industry[J]. Journal of Packaging Technology and Research, 2024, 8(3): 153-166.
[24]	BORJIHAN Qinggele, LIANG Xuefang, CHEN Ting, et al. Biological regulation on iodine using nano-starch for preventing thyroid dysfunction[J]. Journal of Hazardous Materials, 2023, 460: 132200.
[25]	孙锦, 关欣, 寇宗亮, 等. 淀粉纳米颗粒的高效制备及吸附性能[J]. 食品与发酵工业, 2019, 45(9): 108-116.
	SUN Jin, GUAN Xin, KOU Zongliang, et al. Highly efficient preparation of starch nanoparticles and their adsorption capacity[J]. Food and Fermentation Industries, 2019, 45(9): 108-116.
[26]	孙锦, 刘芳, 何会泉, 等. 微波超声波辅助制备木薯淀粉纳米颗粒及其特性表征[J]. 食品工业科技, 2018, 39(20): 128-134, 140.
	SUN Jin, LIU Fang, HE Huiquan, et al. Preparation and characterization of cassava starch nanoparticles with radiation of microwave and ultrasonic[J]. Science and Technology of Food Industry, 2018, 39(20): 128-134, 140.
[27]	MORENO-VÁSQUEZ María J, CARRETAS-VALDEZ Manuel I, LUQUE-ALCARAZ Ana G, et al. Conjugation of lysozyme and epigallocatechin gallate for improving antibacterial and antioxidant properties[J]. Current Microbiology, 2024, 81(9): 264.
[28]	李璐璐, 杨杨, 马春敏, 等. 汉麻蛋白与EGCG复合物的制备及应用[J]. 包装与食品机械, 2024, 42(5): 24-33.
	LI Lulu, YANG Yang, MA Chunmin, et al. The preparation and application of hemp protein and EGCG complex[J]. Packaging and Food Machinery, 2024, 42(5): 24-33.
[29]	李黄炜, 梁茵瑜, 范佳欣, 等. 酶解联合动态高压微射流制备淀粉/百里酚纳米乳液及其结构与性质分析[J]. 食品工业科技, 2024, 45(23): 121-128.
	LI Huangwei, LIANG Yinyu, FAN Jiaxin, et al. Structure and property analysis of starch/thymol nanoemulsion prepared by enzymolysis combined with dynamic high pressure micro-fluidization[J]. Science and Technology of Food Industry, 2024, 45(23): 121-128.
[30]	KARIM Aiman, REHMAN Abdur, KHALIFA Ibrahim, et al. Encapsulation of lutein within ultrasonicated peach gum-sodium caseinate complex nanoparticles via electrostatic complexation: Physiochemical properties, structural interaction mechanisms, and in vitro release analyses[J]. Food and Bioprocess Technology, 2025,18(5): 4392-4409.
[31]	LUO Peihuan, AI Jian, WANG Qiongyao, et al. Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice[J]. Food Chemistry, 2025, 469: 142555.
[32]	ZHU Miao, FEI Xiaoyun, GONG Deming, et al. Effects of processing conditions and simulated digestion in vitro on the antioxidant activity, inhibition of xanthine oxidase and bioaccessibility of epicatechin gallate[J]. Foods, 2023, 12(14): 2807.
[33]	史永桂, 姚先超, 焦思宇, 等. 超声辅助醇沉法制备淀粉纳米颗粒同步包埋叶黄素[J]. 中国食品学报, 2023, 23(9): 160-170.
	SHI Yonggui, YAO Xianchao, JIAO Siyu, et al. Preparation of starch nanoparticles and simultaneously embedding xanthophyll by ultrasound-assisted alcohol precipitation[J]. Journal of Chinese Institute of Food Science and Technology, 2023, 23(9): 160-170.
[34]	YANG Jie, LI Fang, LI Man, et al. Fabrication and characterization of hollow starch nanoparticles by gelation process for drug delivery application[J]. Carbohydrate Polymers, 2017, 173: 223-232.
[35]	段智颖, 王申宛, 艾斌凌, 等. 表没食子儿茶素没食子酸酯-香蕉脱支淀粉纳米颗粒的绿色制备及其性质[J]. 食品科学, 2023, 44(12): 74-83.
	DUAN Zhiying, WANG Shenwan, AI Binling, et al. Green preparation and properties of epigallocatechin-3-gallate loaded debranched banana starch nanoparticles[J]. Food Science, 2023, 44(12): 74-83.
[36]	WANG Shenwan, DUAN Zhiying, ZHENG Lili, et al. Digestive enzyme corona formed in simulated gastrointestinal tract and its impact on EGCG release from banana resistant starch nanoparticles[J]. Food Hydrocolloids, 2024, 146: 109267.
[37]	BARUAH Kamal Narayan, NAGAOKA Satoshi, BANNO Arata, et al. Nano-encapsulation of epigallocatechin gallate using starch nanoparticles: Characterization and insights on in vitro micellar cholesterol solubility[J]. Journal of Food Science, 2024, 89(9): 5701-5711.
[38]	LIU Qing, CAI Wei, ZHEN Tianyuan, et al. Preparation of debranched starch nanoparticles by ionic gelation for encapsulation of epigallocatechin gallate[J]. International Journal of Biological Macromolecules, 2020, 161: 481-491.
[39]	ZHU Song, LIU Bo, WANG Fang, et al. Characterization and in vitro digestion properties of cassava starch and epigallocatechin-3-gallate (EGCG) blend[J]. LWT, 2021, 137: 110398.
[40]	DAI Taotao, LI Ti, HE Xiaohong, et al. Analysis of inhibitory interaction between epigallocatechin gallate and alpha-glucosidase: A spectroscopy and molecular simulation study[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 230: 118023.
[41]	ZHAO Wangchen, LIU Ziyu, LIANG Xiaoyun, et al. Preparation and characterization of epigallocatechin-3-gallate loaded melanin nanocomposite (EGCG @MNPs) for improved thermal stability, antioxidant and antibacterial activity[J]. LWT, 2022, 154: 112599.
[42]	QIAN Yaru, REN Yuhang, CHENG Xiaofang, et al. The physicochemical and antioxidant characteristics of a p-coumaric acid-epigallocatechin gallate-chitosan tyrosinase inhibitor[J]. Food Biophysics, 2024, 19(3): 653-664.
[43]	CHEN Wenjing, JIA Ru, LIU Lu, et al. Comparative study on dynamic in vitro digestion characteristics of lotus seed starch-EGCG complex prepared by different processing methods[J]. Food Chemistry, 2024, 455: 139849.
[44]	LI Zehua, CAI Ming, YANG Kai, et al. Kinetic study of d-limonene release from finger citron essential oil loaded nanoemulsions during simulated digestion in vitro [J]. Journal of Functional Foods, 2019, 58: 67-73.
[45]	RAMESH Nithya, MANDAL Abul Kalam Azad. Pharmacokinetic, toxicokinetic, and bioavailability studies of epigallocatechin-3-gallate loaded solid lipid nanoparticle in rat model[J]. Drug Development and Industrial Pharmacy, 2019, 45(9): 1506-1514.

表没食子儿茶素没食子酸酯的纳米化封装及应用

Nano encapsulation and application of epigallocatechin gallate

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 12

参考文献 45

相关文章 15

编辑推荐

Metrics

本文评价

[1]	屈超, 刘俊红, 贾彬, 黄勇. 水性丙烯酸树脂对PBAT/淀粉复合材料性能影响[J]. 化工进展, 2024, 43(6): 3268-3276.
[2]	尚高原, 余金鹏, 崔凯, 郭坤. 外加电位对高浓度马铃薯淀粉废水电发酵产甲烷系统的影响[J]. 化工进展, 2024, 43(11): 6533-6542.
[3]	杨家添, 唐金铭, 梁恣荣, 黎胤宏, 胡华宇, 陈渊. 新型淀粉基高吸水树脂抑尘剂的制备及其应用[J]. 化工进展, 2023, 42(6): 3187-3196.
[4]	郭宇, 佟民心, 吴红梅. 氨基功能化双醛淀粉吸附剂的制备及其对Pb(Ⅱ)的吸附行为[J]. 化工进展, 2023, 42(12): 6589-6599.
[5]	郑进宝, 李琛. 淀粉基包装材料疏水性改善研究进展[J]. 化工进展, 2022, 41(6): 3089-3102.
[6]	佟欣瑞, 刘彦君, 曹林峰, 毕美营, 董延甲, 吴欣瑜, 谈浚杰, 应明. 可控式citZ基因纳米盒的设计与研究[J]. 化工进展, 2021, 40(S1): 344-349.
[7]	李思远, 李瑞松, 成军, 高萌萌, 张玉苍, 宋辉. 丙烯酰胺改性玉米淀粉/PVA复合膜的制备与表征[J]. 化工进展, 2021, 40(6): 3374-3379.
[8]	刘玉华, 魏宏亮, 李松茂, 刘子君, 李维坤, 王刚. 淀粉基水凝胶的研究进展[J]. 化工进展, 2021, 40(12): 6738-6751.
[9]	邓建辉, 杨晓青, 方称辉, 曹栋清, 李梁君, 张国庆, 郭建维. 静电纺丝/静电喷雾技术在电池领域的应用进展[J]. 化工进展, 2021, 40(10): 5600-5614.
[10]	刘群, 张玉苍. 改性淀粉基生物降解塑料的研究进展[J]. 化工进展, 2020, 39(8): 3124-3134.
[11]	刘土松, 谢新玲, 秦祖赠, 张友全, 朱勇, 蓝艺灵. 水醇淀粉凝胶的形成及多孔淀粉的制备[J]. 化工进展, 2020, 39(12): 5219-5227.
[12]	李丽, 严月根, 吴华明. 一株污泥减量菌喷雾干燥条件的优化[J]. 化工进展, 2019, 38(s1): 193-200.
[13]	李和平, 龚俊, 张淑芬, 张俊, 胡英相. 磁性印迹交联AA/AM接枝酯化氰乙基木薯淀粉微球的制备与吸附性能[J]. 化工进展, 2019, 38(04): 1930-1940.
[14]	余韶阳,安瑛,李守猛,王循,钟强,雷文龙,丁玉梅,杨卫民,李好义. 高黏度聚乳酸（PLA）熔体微分离心静电纺丝[J]. 化工进展, 2019, 38(03): 1176-1181.
[15]	柴琳, 杨文哲, 刘斌, 陈爱强. 多种类型液滴蒸发综述[J]. 化工进展, 2018, 37(S1): 19-28.