基于壳聚糖纳米粒子载药体系的制备与应用研究进展

doi:10.16085/j.issn.1000-6613.2019-0334

摘要/Abstract

摘要：

壳聚糖纳米粒子载药体系因其天然无毒、生物相容性高、可生物降解等特点，在生物医学、化工和食品等领域有广阔的应用前景。本文对制备壳聚糖纳米粒子的离子交联法、聚电解质复合法、乳化交联法、喷雾干燥法和溶剂蒸发法等主要方法进行了综述，并阐述了其制备原理和优缺点。此外，本文结合国内外学者近期的研究工作，综述了壳聚糖纳米粒子载药体系在抗肿瘤药物和抑菌药物方面的应用研究进展，并对壳聚糖装载降糖药物、降脂药物、治疗骨质疏松药物和抗癫痫药物应用进行了简介。最后结合壳聚糖纳米载药体系在制备方法及应用中存在的实际问题，提出多学科研究相结合，开发壳聚糖纳米载药体系的智能控释、靶向递送功能和突破人体特殊生物屏障功能将是其近期的重点研究方向。

关键词: 壳聚糖, 纳米粒子, 制备, 载药体系, 应用

Abstract:

Due to the advantages of non-toxic effects, high biocompatibility and easy biodegradation, chitosan nanoparticle drug-loading system has potential applications in various fields like biomedicine, chemical engineering and food industries. This paper mainly introduces the ionic cross-linking method, polyelectrolyte complex method and emulsification cross-linking method, spray drying method and solvent evaporation method commonly used in the preparation of chitosan nanoparticles, and the characteristics of these methods are summarized. In addition, this paper summarizes the application of chitosan nanoparticle drug-loading system in anti-tumor and antibacterial as well as hypoglycemic, hypolipidemic, osteoporosis and antiepileptic treatment drugs, in combination with recent research work of domestic and foreign scholars. Combined with multidisciplinary research, further development of chitosan nano drug-loading system intelligent controlled release, targeted delivery function and breakthrough of human special biological barrier will be the key research direction in the near future.

Key words: chitosan, nanoparticles, preparation, drug delivery system, application

中图分类号:

TQ464.1

赵海田,李旭东,曹凤芹,倪艳,姚磊. 基于壳聚糖纳米粒子载药体系的制备与应用研究进展[J]. 化工进展, 2019, 38(11): 5057-5065.

Haitian ZHAO,Xudong LI,Fengqin CAO,Yan NI,Lei YAO. Advances in preparation and application of chitosan-based nanoparticles for drug delivery system[J]. Chemical Industry and Engineering Progress, 2019, 38(11): 5057-5065.

图/表 4

参考文献 63

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方法	优点	局限性
离子交联法	操作方便，反应条件温和，完全在水溶液中进行，有利于保持所包封物质的活性	通过弱物理相互作用力形成交联，稳定性相对较差
聚电解质复合法	反应条件温和，避免了有机溶剂的使用和其他物质的引入，纳米粒子在本质上是自发形成的	纳米级的聚电解质络合物胶束必须在很稀的浓度下才能形成；机械强度差、降解速度快
乳化交联法	稳定性好，药物释放平稳、缓慢	所用的交联剂通常带有毒性，如有残留对有机体不利；内在不可切割的共价交联阻碍了在靶点部位的药物释放与扩散
喷雾干燥法	操作简单，易于工业化生产	雾化操作时，芯材暴露于高温环境中易被氧化；囊壁易形成空隙，导致微囊致密性较差，囊壁易于坍塌
溶剂蒸发法	条件温和，适用于疏水性药物	处理条件要求较高，过程伴随高剪切力处理；需使用有机溶剂

方法	优点	局限性
离子交联法	操作方便，反应条件温和，完全在水溶液中进行，有利于保持所包封物质的活性	通过弱物理相互作用力形成交联，稳定性相对较差
聚电解质复合法	反应条件温和，避免了有机溶剂的使用和其他物质的引入，纳米粒子在本质上是自发形成的	纳米级的聚电解质络合物胶束必须在很稀的浓度下才能形成；机械强度差、降解速度快
乳化交联法	稳定性好，药物释放平稳、缓慢	所用的交联剂通常带有毒性，如有残留对有机体不利；内在不可切割的共价交联阻碍了在靶点部位的药物释放与扩散
喷雾干燥法	操作简单，易于工业化生产	雾化操作时，芯材暴露于高温环境中易被氧化；囊壁易形成空隙，导致微囊致密性较差，囊壁易于坍塌
溶剂蒸发法	条件温和，适用于疏水性药物	处理条件要求较高，过程伴随高剪切力处理；需使用有机溶剂

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