Release of cross-linked hyaluronic acid bearing doxorubicin hydrochloride

doi:10.16085/j.issn.1000-6613.2015.11.037

Chemical Industry and Engineering Progree ›› 2015, Vol. 34 ›› Issue (11): 4054-4058.DOI: 10.16085/j.issn.1000-6613.2015.11.037

• Biochemical and pharmaceutical engineering • Previous Articles Next Articles

Release of cross-linked hyaluronic acid bearing doxorubicin hydrochloride

SUN Xiaoqiang¹, LIU Yang¹, CHEN Liang¹, HE Haoming², LI Zhengyi¹

1 School of Petrochemical Engineering, Changzhou University, Changzhou 213164, Jiangsu, China;
2 Changzhou Drug Research Institute Co., Ltd., Changzhou 213164, Jiangsu, China

Received:2015-02-28 Revised:2015-04-02 Online:2015-11-05 Published:2015-11-05

负载盐酸阿霉素交联透明质酸的缓释性能

孙小强¹, 刘扬¹, 陈亮¹, 何浩明², 李正义¹

1 常州大学石油化工学院, 江苏常州 213164;
2 常州药物研究所有限公司, 江苏常州 213164

通讯作者: 李正义,副教授,从事有机合成及超分子化学相关研究。E-mailzyli@cczu.edu.cn。
作者简介:孙小强(1956—),男,博士,教授,从事有机合成及药物相关研究。
基金资助:
国家自然科学基金(21002009)、江苏省高校自然科学研究重大项目(12KJA150002,14KJA150002)及江苏省青蓝工程项目。

Abstract

Abstract: Using anti-cancer drug doxorubicin hydrochloride and cross-linking hyaluronic acid as a model and a carrier respectively, a series of cross linking hyaluronic acid films bearing different loadings of doxorubicin hydrochloride and sustained-release activities have been prepared by swelling in the sorption of drug molecules, freeze-drying, and crushing. Their microstructures and drug release behaviors in vitro were investigated by SEM and ultraviolet spectrophotometer, respectively. The effects of different time, drug loadings and hyaluronidase, on drug release behavior were studied, and the results showed that the drug releases fast within 12 h, then gets slow, the drug cumulative release speed is inversely proportional to drug loading, and the drug cumulative release speed in the presence of hyaluronidase is faster than that without hyaluronidase because of the continuously degradation of cross-linked hyaluronic acid.

Key words: cross-linking hyaluronic acid, doxorubicin hydrochloride, drug sustained release, degradation

摘要： 以抗癌药物盐酸阿霉素为模型,交联透明质酸为载体,通过溶胀作用吸附药物分子,再冷冻干燥、碾压成形,制备了一系列具有不同载药量和一定缓释效果的载药交联透明质酸膜。通过SEM观测其微结构,利用紫外分光光度法检测其药物体外释放行为,并研究不同释放时间、载药量和透明质酸酶对药物释放行为的影响。结果表明,12h内药物释放较快,随后释放平缓,药物累积释放速度与载药量呈反比;加入透明质酸酶后,由于交联透明质酸的不断降解,药物累积释放速度比无透明质酸酶时快。

关键词: 交联透明质酸, 盐酸阿霉素, 药物缓释, 降解

CLC Number:

R318

SUN Xiaoqiang, LIU Yang, CHEN Liang, HE Haoming, LI Zhengyi. Release of cross-linked hyaluronic acid bearing doxorubicin hydrochloride[J]. Chemical Industry and Engineering Progree, 2015, 34(11): 4054-4058.

孙小强, 刘扬, 陈亮, 何浩明, 李正义. 负载盐酸阿霉素交联透明质酸的缓释性能[J]. 化工进展, 2015, 34(11): 4054-4058.

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Release of cross-linked hyaluronic acid bearing doxorubicin hydrochloride

负载盐酸阿霉素交联透明质酸的缓释性能

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