Abstract: The grey system theory was applied to the Flavomycin flask fermentation. The influence of operational parameters on Flavomycin flask fermentation was sequenced by grey relational analysis. The grey forecasting model GM(1,7) was developed to predict the yield of fermentation products. The order of grey relational analysis was total suger，amino nitrogen，pH，reducing suger，biomass of seed broth and residual oil. The yield of flavomycin shows a positive correlation with biomass of seed broth and pH，while it shows the negative correlation with total suger，reducing suger，amino nitrogen and residual oil. The predicted data of GM(1,7) agree well with experimental data. The average relative error is 4.804%. It indicates that the grey relational analysis and the grey forecasting model are valid for the Flavomycin flask fermentation.

Key words: Flavomycin, fermentation, grey relational analysis, grey forecasting model, Flavomycin, fermentation, grey relational analysis, grey forecasting model

摘要： 将灰色理论应用于黄霉素摇瓶发酵过程。对黄霉素摇瓶发酵过程中的各控制因素进行了灰色关联度分析，并建立了GM（1,7）灰色模型。结果表明不同参数对摇瓶发酵过程中黄霉素效价的影响程度是不同的，其影响顺序为：总糖＞氨基氮＞pH值＞还原糖＞种子液生物量＞残油；黄霉素的发酵生产与种子液生物量和pH值呈正相关性，与总糖、还原糖、氨基氮和残油呈负相关性；GM（1,7）灰色模型的平均相对误差仅为4.804%，预测模拟的结果较好。这说明灰色理论中的灰色关联度分析和灰色预测模型可以很好的应用于黄霉素的发酵过程。

关键词: 黄霉素, 发酵, 灰色关联度分析, 灰色预测模型, 黄霉素, 发酵, 灰色关联度分析, 灰色预测模型