Abstract:

Green bio-manufacturing is the process of producing bio-based products, such as chemicals, energy, food, and medicine from renewable feedstocks through biological processes and biological systems. Its green and clean production process is conducive to overcoming the traditional chemical industry's "high dependence" on fossil resources and the problems of "high energy consumption" and "high emissions". Aliphatic short-chain diamines and diols are significant bulk chemicals with a wide range of applications in cosmetics, pharmaceuticals and other industrial fields. They can be utilized as polymeric monomers in the manufacture of polyester, polyurethane, polyamide, and other polymer materials. In this review, the biosynthesis of aliphatic short-chain diamines, including 1,3-propanediamine, 1,4-butanediamine, 1,5-pentanediamine, aliphatic short-chain diols, including 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol from renewable raw materials is reviewed. The carbon cycle and metabolic pathways of bio-manufacturing from renewable feedstocks are compiled. The de novo biosynthesis routes of aliphatic short-chain diamines and diols are summarized. The current state of research on the biosynthesis of short-chain diamines and diols using lignocellulose hydrolyzed sugars, glycerol and one-carbon compounds as feedstocks is described. The primary challenges in the bio-manufacturing of aliphatic short-chain diamines and diols are discussed and prospected.

Key words: synthetic biology, biological engineering, biomass, biocatalysis

摘要：

绿色生物制造是以生物质等可再生原料通过生物过程和生物系统生产生物基材料、化学品、能源、医药和食品等，其绿色清洁的生产工艺有助于改善传统化工行业对化石资源高依赖以及工艺高能耗、高排放等问题。脂肪族短链二元胺和醇是重要的大宗化学品，可作为聚合单体应用于合成聚酯、聚氨酯、聚酰胺等高分子材料，同时在化妆品、制药等领域具有广泛应用。本文全面探讨了利用可再生原料生物合成1,3-丙二胺、1,4-丁二胺、1,5-戊二胺、1,3-丙二醇、1,4-丁二醇、1,5-戊二醇的研究进展，概况了可再生原料生物制造的碳循环和代谢途径，总结了脂肪族短链二元胺和二元醇的从头生物合成路线，阐述了利用木质纤维素水解糖、甘油、一碳化合物原料合成短链二元胺和醇的研究现状。并对脂肪族短链二元胺和醇生物制造主要面临的挑战进行了相关讨论和展望。

关键词: 合成生物学, 生物工程, 生物质, 生物催化