Chemical Industry and Engineering Progress ›› 2023, Vol. 42 ›› Issue (7): 3684-3694.DOI: 10.16085/j.issn.1000-6613.2022-1595

• Biochemical and pharmaceutical engineering • Previous Articles     Next Articles

Research progress of nanomaterials for synergistic ferroptosis anticancer therapy

XU Peiyao1,2(), CHEN Biaoqi1,2, KANKALA Ranjith Kumar1,2, WANG Shibin1,2, CHEN Aizheng1,2()   

  1. 1.Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, Fujian, China
    2.Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, Fujian, China
  • Received:2022-08-29 Revised:2022-09-08 Online:2023-08-14 Published:2023-07-15
  • Contact: CHEN Aizheng

纳米材料用于铁死亡联合治疗的研究进展

徐沛瑶1,2(), 陈标奇1,2, KANKALA Ranjith Kumar1,2, 王士斌1,2, 陈爱政1,2()   

  1. 1.华侨大学生物材料与组织工程研究所,福建 厦门 361021
    2.福建省生物化工技术重点实验室,福建 厦门 361021
  • 通讯作者: 陈爱政
  • 作者简介:徐沛瑶(1995—),女,博士,讲师,研究方向为纳米医学。E-mail:xupeiyao@hqu.edu.cn
  • 基金资助:
    国家重点研发计划政府间国际科技创新合作重点专项(2019YFE0113600);国家自然科学基金(81971734);华侨大学高层次人才科研启动费项目(21BS113)

Abstract:

Ferroptosis, a programmed cell death modality, has been recognized as one of the exceptional cancer therapeutic strategies. However, the complexity of anatomical and physiological features of tumor microenvironment may weaken the ferroptosis effects for cancer treatment. Fortunately, the combination of ferroptosis with traditional therapeutics provides an easy way of improving the therapeutic efficiency and reducing toxic side effects due to lesser dosages of multiple drugs. Nanomaterials-based drug delivery systems have served as potential anticancer drug agents in clinical translation, which can achieve the tumor-targeted delivery of various practical molecules and improve therapeutic efficiency based on synergistic strategies. In this review, we systematically summarized various novel nanoplatforms (iron-based nanomaterials and nor-iron nanomaterials) for ferroptosis-based combination therapeutics towards highly effective cancer therapy. Then, we provided a brief emphasis on the combination of ferroptosis with multiple strategies, including chemotherapy, photothermal therapy, photo/sonodynamic therapy, and other therapeutics. Finally, we presented various challenges towards developing ferroptosis-based therapeutic strategies, and we believed that the deeper understanding of ferroptosis, the development of multifunctional nanomaterials and the exploration of ferroptosis-based combination therapies would be focus in future.

Key words: nanomaterials, pharmaceuticals, ferroptosis, radical, anticancer

摘要:

铁死亡作为一种新发现的调节性细胞死亡形式已成为新型的肿瘤治疗策略,然而复杂的肿瘤微环境及肿瘤部位特殊的病理微环境严重限制了铁死亡的治疗效果。将铁死亡与传统的抗肿瘤治疗方式结合,能提高治疗效率并减少毒副作用。为实现药物在肿瘤部位富集效果并发挥协同治疗效果,基于纳米材料的药物递送体系在抗肿瘤领域显示出广阔的临床应用前景和发展价值。本文首先介绍了不同种类纳米材料(铁基纳米材料及非铁基纳米材料)用于铁死亡协同肿瘤治疗的相关进展,归纳了铁死亡与多种治疗方法(包括化学治疗、光热治疗、光/声动力治疗、其他治疗方式等)协同治疗的相关研究;最后阐明了铁死亡协同肿瘤治疗的挑战,并指出确认铁死亡的具体抗癌机制、开发多功能纳米材料并探索高效协同治疗手段将是未来的研究方向。

关键词: 纳米材料, 药物, 铁死亡, 自由基, 抗肿瘤

CLC Number: 

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