Abstract: Molecular imprinting technology has been developed rapidly in recent years and applied in various fields，including separation engineering，chemical sensors and analogy enzyme catalysis，due to its high selectivity，specific recognition and so on. However，a little attention has been paid to molecularly imprinted hydrogels. Temperature-sensitive molecularly imprinted hydrogels，obtained by combining molecular imprinting technique with temperature-sensitive hydrogels，provide both the specific identification properties and stimuli-responsiveness to the environment temperature changes，which means that the specific recognition of such hydrogels to the template molecules changes with temperature variation. This paper is aimed to not only review the specific identification principle and preparation approaches of temperature-sensitive molecularly imprinted hydrogels，but also to highlight the application of temperature-sensitive molecularly imprinted hydrogels in metal-ion，organic molecules and protein imprinting. In this review，the possible development of temperature-sensitive molecularly imprinted hydrogels is prospected，which will show enormous potential applications in many fields，such as material separation and drug controlled release system.

Key words: molecular imprinting, gels, N-isopropylacrylamide, polymers, selectivity

摘要： 近年来分子印迹技术发展迅速，以其高选择性、预定识别性等优点，在分离工程、化学传感器及模拟酶催化等领域均得到了广泛应用，但是其在水凝胶方面的研究却较少。将温敏水凝胶引入分子印迹技术制备温敏印迹水凝胶不仅能保持其特异识别性能，还赋予其对环境温度变化的响应性，使其对模板分子的识别具有温度可控性。本文简单介绍了温敏型分子印迹水凝胶的基本原理和制备方法，基于模板分子种类的不同，着重综述了温敏印迹凝胶在金属离子、有机小分子及生物蛋白方面的应用。同时对温敏印迹水凝胶的发展方向进行了展望，指出温敏印迹水凝胶将在物料分离、药物控释等领域表现出较好的应用前景。

关键词: 分子印迹, 凝胶, N-异丙基丙烯酰胺, 聚合物, 选择性