Preparation of ionic covalent organic framework materials and their adsorption properties for non-steroidal anti-inflammatory drugs

doi:10.16085/j.issn.1000-6613.2024-1742

Abstract

Abstract:

In recent years, ionic covalent organic frameworks (iCOFs) have been used as preferred adsorbents in the field of environmental remediation. Herein, a sheet iCOFs (COF_DHA-TAGH) was prepared by Schiff base condensation of 2,5-dihydroxyp-phenyldiformaldehyde (DHA) and positively charged triaminoguanidine hydrochloride (TAGH) for adsorption of non-steroidal anti-inflammatory drug indomethacin (IDM). COF_DHA-TAGH's evenly distributed adsorption sites and abundant surface functional groups (guanidine, hydroxyl and aromatic groups) contributed to its efficient removal of IDM by electrostatic, hydrogen bonding and π-π interactions. The effects of pH and adsorption time on the adsorption of IDM by COF_DHA-TAGH were investigated. The results showed that the adsorption of IDM by COF_DHA-TAGH conformed to the pseudo-second-order kinetic model and Langmuir adsorption model, and the maximum adsorption capacity could reach 498mg/g. This work provided a new approach and useful references for removing non-steroidal anti-inflammatory drugs from pharmaceutical wastewater.

Key words: ionic covalent organic framework, non-steroidal anti-inflammatory drugs, indomethacin, adsorb

摘要：

近年来，离子型共价有机框架（iCOFs）材料被作为环境修复领域中的优选吸附剂。因此，本文利用2,5-二羟基对苯二甲醛（DHA）与带正电荷的三氨基胍盐酸盐（TAGH）通过席夫碱缩合制备了一种薄片状iCOFs（COF_DHA-TAGH），用于吸附去除非甾体抗炎药吲哚美辛（IDM）。COF_DHA-TAGH均匀分布的吸附位点、表面丰富的官能团（胍基、羟基和芳香基团）有助于其通过静电、氢键和π-π相互作用高效去除IDM。考察了pH和吸附时间对COF_DHA-TAGH吸附IDM过程的影响。结果表明，COF_DHA-TAGH对IDM的吸附符合伪二级动力学模型和Langmuir吸附模型，最大吸附量可达498mg/g。本工作为从药物废水中去除非甾体抗炎药提供了新的途径和有益参考。

关键词: 离子型共价有机框架, 非甾体类药物, 吲哚美辛, 吸附

CLC Number:

WANG Le, XU Qiaoying, KUANG Renyun, ZENG Keni, FU Wenjie, HOU Linli. Preparation of ionic covalent organic framework materials and their adsorption properties for non-steroidal anti-inflammatory drugs[J]. Chemical Industry and Engineering Progress, 2025, 44(11): 6737-6746.

王乐, 徐桥英, 匡仁云, 曾可妮, 傅文杰, 候林丽. 离子型共价有机框架材料的制备及对非甾体类抗炎药的吸附性能[J]. 化工进展, 2025, 44(11): 6737-6746.

Figures/Tables 14

References 28

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伪一级动力学模型				伪二级动力学模型
q_e/mg·g^-1	K₁/min^-1	R^２		q_e/mg·g^-1	K₂/g·mg^-1·min^-1	R^２
294	0.05805	0.94876		497.51	0.00074	0.99704

伪一级动力学模型				伪二级动力学模型
q_e/mg·g^-1	K₁/min^-1	R^２		q_e/mg·g^-1	K₂/g·mg^-1·min^-1	R^２
294	0.05805	0.94876		497.51	0.00074	0.99704

Langmuir模型				Freundlich模型
q_max/mg·g^-1	K_L/L·mg^-1	R^２		K_F/mg·g^-1·(mg·L)^-1/ⁿ	n	R^２
473.93	0.22860	0.98666		103.85	2.34582	0.95784

Langmuir模型				Freundlich模型
q_max/mg·g^-1	K_L/L·mg^-1	R^２		K_F/mg·g^-1·(mg·L)^-1/ⁿ	n	R^２
473.93	0.22860	0.98666		103.85	2.34582	0.95784

吸附剂	目标吸附药物	最大吸附量/mg·g^-1	比表面积/m²·g^-1	平衡时间/h	参考文献
COF-NO₂	布洛芬	94	679	2	[12]
OH-MCOF	双氯芬酸钠	203	89.80	0.5	[13]
MCC/COF/PANI	吲哚美辛	149.1	69.86	1	[22]
COF-3-NH₂	双氯芬酸钠	410	114	1	[28]
iCOFs	吲哚美欣	498	34.63	1	本次工作