Research progress on the regulation of signal molecule AI-2 during sludge granulation

doi:10.16085/j.issn.1000-6613.2023-1376

Abstract

Abstract:

Quorum sensing is a communication mechanism widely existing in microorganisms. Autoinducer-2 (AI-2), a kind of quorum sensing signaling molecule for interspecies communication, has received increasing attention for its role in regulating bacterial gene expression and aggregation. Granular sludge, as a kind of microbial aggregates, has been widely concerned and studied because of its advantages such as high microbial population, good settleability and high resistance to loads. A large number of studies have shown that AI-2 mediated quorum sensing plays an important role in the process of sludge granulation. This paper reviewed the formation of AI-2 signaling molecules and the mechanism of AI-2 mediated quorum sensing, the detection methods of AI-2, the influencing factors in the production of AI-2 and its distribution in granular sludge, summarized the regulatory role of AI-2 in the process of granulation, and finally provided an outlook of the research of AI-2 mediated quorum sensing in granular sludge. The aim is to provide theoretical references for the in-depth understanding of the regulation effect of quorum sensing on sludge granulation as well as for promoting the engineering application of sludge granulation.

Key words: granular sludge, quorum sensing, autoinducer-2 (AI-2), regulatory effect

摘要：

群体感应是广泛存在于微生物间的信息交流机制，autoinducer-2（AI-2）作为一种“种间通讯”的群体感应信号分子，因其在调节细菌基因表达和聚集中的作用而受到越来越多的关注。颗粒污泥作为一种微生物聚集体，因其具有微生物量多、沉降性好、抗负荷冲击能力强等优点而得到广泛的关注和研究。大量的研究表明AI-2介导的群体感应在污泥颗粒化过程中发挥着重要调控作用。本文综述了AI-2信号分子的形成和介导的群体感应作用机制、AI-2的检测方法、AI-2形成中的影响因素与在颗粒污泥中的分布，总结了AI-2在颗粒化过程中的调控作用，最后对AI-2介导群体感应在颗粒污泥中的研究进行了展望，旨在为深入理解群体感应对污泥颗粒化的调控作用以及推进污泥颗粒化的工程应用提供理论参考。

关键词: 颗粒污泥, 群体感应, AI-2, 调控作用

CLC Number:

X703

LI Songya, CHEN Binghua, LIU Biao, WANG Linpei, WANG Le, GU Deming, ZHOU Yiming, WANG Xiaoyan. Research progress on the regulation of signal molecule AI-2 during sludge granulation[J]. Chemical Industry and Engineering Progress, 2024, 43(9): 5217-5225.

李松亚, 陈炳桦, 刘彪, 王林裴, 王乐, 谷得明, 周一鸣, 王笑艳. 污泥颗粒化过程中信号分子AI-2调控作用研究进展[J]. 化工进展, 2024, 43(9): 5217-5225.

Figures/Tables 3

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菌属	作用	群体感应调控作用
Aeromonas	尚不明确	生物膜形成
Arcobacter	尚不明确	尚不明确
Bacillus	尚不明确	孢子形成
Corynebacterium	尚不明确	尚不明确
Vibrio	潜在病原体	生物膜形成，毒性

菌属	作用	群体感应调控作用
Aeromonas	尚不明确	生物膜形成
Arcobacter	尚不明确	尚不明确
Bacillus	尚不明确	孢子形成
Corynebacterium	尚不明确	尚不明确
Vibrio	潜在病原体	生物膜形成，毒性

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