Optimization of ultrasonic crystallization process of riboflavin

doi:10.16085/j.issn.1000-6613.2020-0585

Abstract

Abstract:

Riboflavin is widely used as medicine, pigment, nutritional additives, and feed additives. At present, riboflavin in production and sale is mostly needle-like crystals with low bulk density, poor dispersion and fluidity, which affects the processing performance, e.g. tableting. In this paper, five methods of riboflavin crystal purification, such as acid dissolving method and alkali dissolving method, were screened, and the comprehensive benefit of the yield and purity of acid dissolving method was found to be the best; on this basis, ultrasonic assisted crystallization was used to optimize the power, time and temperature, and the results were analyzed by transmission electron microscopy (TEM) and X-ray diffraction (XRD) and other characterization methods. The results show that the optimum parameters for ultrasonic crystallization are: the ultrasonic power is 400W, the ultrasonic time is 40 minutes, and the ultrasonic temperature is 50℃, the yield of riboflavin can reach 95%, and the purity is more than 96%. The crystal habit and crystallinity of riboflavin are improved, which is convenient for its processing and application.

Key words: riboflavin, ultrasonic crystallization, process, optimization, purification

摘要：

核黄素作为药品、色素、营养及动物饲料添加剂被广泛应用，目前生产及销售的核黄素基本上都是针状晶习，其堆密度小、分散性和流动性差，影响压片等加工性能。本文对酸溶法、碱溶法等5种核黄素结晶纯化方法进行了筛选，发现酸溶法收率和纯度的综合效益最佳；在此基础上采用超声辅助结晶，对功率、时间及温度进行优化，通过透射电镜（TEM）及X射线衍射分析法（XRD）等表征方法对结果进行分析。最终确定超声结晶的最佳实验条件为：超声功率为400W，超声时间为40min，超声温度为50℃，核黄素的收率可达到95%，纯度超过96%。核黄素晶习和结晶度有所改善，便于加工应用。

关键词: 核黄素, 超声结晶, 工艺, 优化, 纯化

CLC Number:

Liang CHEN, Feibao TIAN, Xiulan XIN, Rong LAN, Ran YU, Zhiming WU, Hao LIANG. Optimization of ultrasonic crystallization process of riboflavin[J]. Chemical Industry and Engineering Progress, 2021, 40(2): 1018-1024.

陈亮, 田飞豹, 辛秀兰, 兰蓉, 于然, 吴志明, 梁浩. 核黄素超声结晶工艺优化[J]. 化工进展, 2021, 40(2): 1018-1024.

Figures/Tables 8

References 32

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序号	收率/%	纯度/%	综合收益/%
溶剂析出法	88.90±2.13	96.56±1.09	85.84±3.03
溶剂析出结合酸溶法	92.7±1.89	94.19±1.25	87.31±2.94
控制结晶法	93.79±1.64	93.03±1.89	87.25±3.30
酸溶法	95.24±1.73	97.15±2.10	92.53±3.68
碱溶法	90.90±2.35	89.08±1.57	80.97±3.52

序号	收率/%	纯度/%	综合收益/%
溶剂析出法	88.90±2.13	96.56±1.09	85.84±3.03
溶剂析出结合酸溶法	92.7±1.89	94.19±1.25	87.31±2.94
控制结晶法	93.79±1.64	93.03±1.89	87.25±3.30
酸溶法	95.24±1.73	97.15±2.10	92.53±3.68
碱溶法	90.90±2.35	89.08±1.57	80.97±3.52

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