Inhibition activity of lipid peroxidation of quinoxalinone compounds

doi:10.16085/j.issn.1000-6613.2016.01.029

Chemical Industry and Engineering Progree ›› 2016, Vol. 35 ›› Issue (01): 216-219.DOI: 10.16085/j.issn.1000-6613.2016.01.029

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Inhibition activity of lipid peroxidation of quinoxalinone compounds

QIN Xiangyu, ZHU Changjin

School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China

Received:2015-04-27 Revised:2015-05-21 Online:2016-01-05 Published:2016-01-05

喹喔啉化合物的脂质过氧化活性

秦祥宇, 朱长进

北京理工大学化工与环境学院, 北京 100081

通讯作者: 朱长进,教授。E-mail:zcj@bit.edu.cn。
作者简介:秦祥宇(1988-),男,博士研究生。E-mail:qxyszgr@163.com。
基金资助:
国家自然科学基金项目(21272025)。

Abstract

Abstract: A series of synthesized quinoxalinone compounds have been investigated for their inhibition of lipid peroxidation. The activity data of in vitro and in vivo inhibition of lipid peroxidation has been obtained. These quinoxalinone compounds were found to have excellent antioxidant activity. 2-(3-(3-methoxy-4-hydroxystyryl)-2-oxoquinoxalin-1(2H)-yl) acetic acid showed appreciable antioxidant properties, much more potent than other tested compounds, with the inhibition value of 57.7%. Further structure activity relationship analysis demonstrates the importance of the para-hydroxystyryl structure for the quinoxaline derivatives in the antioxidant activity.

Key words: organic compounds, quinoxalinone, antioxidant, pharmaceuticals

摘要： 研究了一系列先前合成的喹喔啉化合物的抑制脂质过氧化活性,实验得到了这些化合物的体内和体外脂质过氧化抗氧化活性数据,发现这类喹喔啉化合物具有优异的抗氧化活性,其中,脂质过氧化清除率最高的化合物是2-(3-(3-甲氧基-4-羟基苯基)-2氧喹喔啉-1(2H)-烷基)乙酸,它在浓度为100μmol/L时,对应的清除率达到了57.7%。构效关系研究认为对羟基苯乙烯这一结构单元对于喹喔啉化合物在提高抗氧化活性有重要意义。

关键词: 有机化合物, 喹喔啉, 抗氧化, 药物

CLC Number:

TQ460

QIN Xiangyu, ZHU Changjin. Inhibition activity of lipid peroxidation of quinoxalinone compounds[J]. Chemical Industry and Engineering Progree, 2016, 35(01): 216-219.

秦祥宇, 朱长进. 喹喔啉化合物的脂质过氧化活性[J]. 化工进展, 2016, 35(01): 216-219.

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Inhibition activity of lipid peroxidation of quinoxalinone compounds

喹喔啉化合物的脂质过氧化活性

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