Abstract: The progress of the integrated utilization of spent brewer’s yeast cells is presented. Spent brewer’s yeast cells utilized as new protein sources，like nutritional yeast，isolated protein，bioactive peptide and amino acid，as functional flavoring and as new sources for extraction of bioactive substances，like β-glucan，mannan，trehalose，SOD，and GSH have been emphasized，which in order to indicate the importance of the integrated utilization of spent brewer’s yeast.