Abstract: Poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)(PND) and poly(N-isopropyl- acrylamide-co-butyl methacrylate) (PNB) were prepared by copolymerizing hydrophilic monomer N,N-dimethylacrylamide (DMAA) or hydrophobic monomer butyl methacrylate (BMA) with the monomer N-isopropylacrylamide (NIPAM). Both the volume phase transition temperature in water and ethanol-sensitive characteristics at different temperatures below the lower critical solution temperature (LCST) of the copolymers were investigated systematically for the first time. The results showed that temperature- and ethanol-sensitive characteristics of the polymers could be controlled by properly introducing hydrophilic or hydrophobic groups into the copolymers.