Abstract: Clindamycin phosphate as an antibiotic medicine is the third generation product of Lincomycin. It is widely used in clinical applications. Some compounds with similar structures in clindamycin phosphate raw material make the purification difficult．Nowadays，cooling combined with dilute crystallization is the most important technique to purify and obtain good crystalline quality of clindamycin phosphate. In this work，the solvent composition，cooling method and rate，stirring rate were investigated to disclose their influence on the quality including：purity，crystal size distribution，crystal size，content of residual solvent. The optimum operation conditions were provided.