Fe3O4磁性纳米复合材料的制备及载药性能

doi:10.16085/j.issn.1000-6613.2016.s1.043

化工进展 ›› 2016, Vol. 35 ›› Issue (S1): 265-269.DOI: 10.16085/j.issn.1000-6613.2016.s1.043

Fe₃O₄磁性纳米复合材料的制备及载药性能

常娟娟¹, 李波¹, 刘文¹, 王浩江¹, 郭睿¹, 董川², 乔洁¹

1. 山西医科大学基础医学院, 山西太原 030001;
2. 山西大学环境科学与工程研究中心, 山西太原 030006

收稿日期:2015-12-08 修回日期:2016-01-05 出版日期:2016-06-30 发布日期:2016-07-08
通讯作者: 乔洁,副教授。E-mail qiaojie@sxu.edu.cn。
作者简介:常娟娟(1989-),女,硕士研究生。E-mail 1643411092@qq.com。
基金资助:
山西省自然科学基金项目(2013011012-5)。

Preparation and drug loading properties of Fe₃O₄ magnetic nanocomposite

CHANG Juanjuan¹, LI Bo¹, LIU Wen¹, WANG Haojiang¹, GUO Rui¹, DONG Chuan², QIAO Jie¹

1. School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, Shanxi, China;
2. Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, Shanxi, China

Received:2015-12-08 Revised:2016-01-05 Online:2016-06-30 Published:2016-07-08

摘要/Abstract

摘要： 利用聚乙二醇水溶性高及良好的生物相容性等特性对Fe₃O₄磁性纳米粒子进行表面改性,从而改善Fe₃O₄易于团聚的缺陷。通过一步法制备具有核壳结构的聚乙二醇/Fe₃O₄磁性纳米复合材料,使用FTIR、XRD、TEM和VSM对复合纳米材料的结构、形貌和性能进行了表征。采用超声法合成了阿霉素聚乙二醇修饰的Fe₃O₄磁性纳米包合物,用光度法对磁性纳米复合物的包封率进行了系统的分析,平均包封率为54.83%,并通过四唑盐(MTT)比色法证明了包合物对K150细胞有明显的抑制作用。研究结果表明:合成的磁性纳米复合材料拥有良好的形貌和载药性能,可作为一种新型的药物载体以达到靶向运输的效果,从而提高药物的生物利用度。

关键词: 聚乙二醇, 阿霉素, 磁性纳米材料, MTT比色法

Abstract: The surface modification of Fe₃O₄ magnetic nanoparticles was carried out by using polyethylene glycol with the characteristics of high water solubility and good biocompatibility, to improve the defects of Fe₃O₄.The polyethylene glycol-Fe₃O₄ magnetic nanocomposite with core-shell structure was prepared by one-step method.The structure, morphology and properties of the composites were characterized by XRD, TEM, FTIR and VSM.Fe₃O₄ magnetic nanoparticles modified by adriamycin and polyethylene glycol were synthesized by the ultrasonic method, the encapsulation efficiency of magnetic nanocomposite was analyzed by spectrophotometry, and the average encapsulation efficiency was 54.83%.In addition, it was proved that the inclusion compound had obvious inhibitory effect on K150 cells by MTT olorimetric assay.The results showed that the synthesis of magnetic nanocomposite had good morphology and drug loading properties, and they can be used as a novel drug carrier to achieve the effect of targeted delivery and further improve the bioavailability of the drug.

Key words: polyethylene glycol (PEG), Adriamycin, magnetic nanomaterials, MTT colorimetry

中图分类号:

O614.811

常娟娟, 李波, 刘文, 王浩江, 郭睿, 董川, 乔洁. Fe₃O₄磁性纳米复合材料的制备及载药性能[J]. 化工进展, 2016, 35(S1): 265-269.

CHANG Juanjuan, LI Bo, LIU Wen, WANG Haojiang, GUO Rui, DONG Chuan, QIAO Jie. Preparation and drug loading properties of Fe₃O₄ magnetic nanocomposite[J]. Chemical Industry and Engineering Progree, 2016, 35(S1): 265-269.

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Fe₃O₄磁性纳米复合材料的制备及载药性能

Preparation and drug loading properties of Fe₃O₄ magnetic nanocomposite

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