Progress in the catalyst for reductive amination of alcohol

doi:10.16085/j.issn.1000-6613.2017-2302

Abstract

Abstract: Reductive amination of alcohol is one of the most effective and promising methods for the synthesis of amine, and the high-performance catalyst is the core. The progress in homogeneous catalysts of Ru, Ir, Pd, Cu, and nonmetallic ones and heterogeneous catalysts of Co, Ni, Ru, Pd, et al. for reductive amination of alcohols was outlined in detail respectively in this paper. The catalytic performance and reaction regularity of different catalytic systems were discussed together with their respective characteristics and limitations. Finally, it is pointed out that the application of homogeneous catalytic system is limited by the recovery problem. The research should focus on the development of efficient and cheap catalytic systems, the expansion of their applications and the recovery of the catalyst. The heterogeneous reaction catalysts are of high specificity and the performance is difficult to meet the need of industrial application. The studies on the microstructure and the reaction mechanism of high performance catalyst, flow field state and process of high pressure system should be strengthened to improve the activity, selectivity and stability of the catalysts.

Key words: alcohol, reductive amination, catalyst, amine, synthesis

摘要： 醇还原胺化反应是胺合成最有效、最有应用潜力的方法之一，而催化剂是还原胺化反应的关键。本文详细阐述了Ru、Ir、Pd、Cu、非金属等均相催化剂和Co、Ni、Ru、Pd等非均相催化剂在醇还原胺化反应中的研究进展，介绍了不同催化体系的催化性能和反应规律、应用特点和局限性。指出了均相催化体系的回收使用仍然是阻碍其应用的难题，研究重点应集中在高效、廉价催化体系开发、拓展应用范围和分离回收研究；非均相反应催化剂的专用性强，性能难以满足工业应用需求，加强微观结构及反应机理、高性能催化剂、高压体系中流场状态与过程研究以及提高活性、选择性和稳定性是未来的研究重点。

关键词: 醇, 还原胺化, 催化剂, 胺, 合成

CLC Number:

YU Qinwei, HUI Feng, ZHANG Qian, YUAN Jun, WANG Weiqiang, ZHAO Fengwei, YANG Jianming, LÜ Jian. Progress in the catalyst for reductive amination of alcohol[J]. Chemical Industry and Engineering Progress, 2018, 37(10): 3832-3842.

余秦伟, 惠丰, 张前, 袁俊, 王为强, 赵锋伟, 杨建明, 吕剑. 醇还原胺化反应催化剂研究进展[J]. 化工进展, 2018, 37(10): 3832-3842.

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