Abstract: This review described the mechanism of N-acyl homoserine lactone (AHL) style quorum sensing (QS) signal molecules for microorganisms to biofilm formation on the surface of membrane in membrane bioreactors (MBRs). Through the cell-cell communication between microorganisms，the QS determines biofilm formation and secretion of extracellular polymeric substances (EPS). The article summarized studies on the inhibition or disruption of AHL-QS signaling molecules by AHL-acylase or quorum quenching and effectively controlled membrane biofouling. The signaling molecules reduction would weaken biofilm formation ability but enhance membrane filterability. Moreover，the paper reviewed new immobilized methods about the AHL-acylase or quorum quenching，such as immobilized magnetic carriers，membrane surface，microbial-vessel and cell entrapping beads. The QS control strategies offered a promising control alternative but more investigations on the application to real MBRs were needed. Future studies should specifically address the relationship between the QS and microbial metabolism，as well as signaling molecules recognition in real MBR system.

Key words: membrane bioreactors(MBRs), membrane fouling, biofilm, quorum sensing(QS), N-acyl homoserine lactone(AHL)

摘要： 首先介绍N-乙酰高丝氨酸环内酯（N-acyl homoserine lactone，AHL）型生物群体感应（quorum sensing，QS）信号分子对膜生物反应器（membrane bioreactor，MBR）膜表面形成生物膜的调节机制，通过AHL-QS信号分子细胞间的交流，可决定生物膜形成及胞外聚合物（extracellular polymeric substances，EPS）分泌；系统阐述了应用AHL-QS信号分子降解酶及淬灭剂对MBR生物膜污染的控制效果，抑制或降解信号分子可显著降低生物膜形成能力，从根本上控制膜污染。此外，针对降解酶及淬灭剂新的固定化技术在MBR中的应用也作了介绍，如磁性载体、膜表面负载、微生物-管束及多孔微球包埋细胞技术。以AHL-QS为基础的膜污染控制策略对于MBR应用前景广阔，然而该技术的工程化研究仍有待进一步深入；加强AHL-QS信号分子识别及进一步明确QS系统对微生物代谢机制的影响是该领域未来重要的研究方向。

关键词: 膜生物反应器, 膜污染, 生物膜, 群体感应, N-乙酰高丝氨酸环内酯