Abstract: Serinol，an important intermediate for several chemical processes，is widely used in medicine，chemical industry and other fields. The current synthesis route of serinol mainly uses the chemical methods based on chemicals like 2-nitro-1,3-propanediol and dihydroxyacetone oxime，which are suffering from high pollution，high energy consumption and difficult purification. Meanwhile，biological methods，based on transaminases，are receiving increasing attention because of its environmental friendliness and low energy consumption. In this review，the chemical and biological synthesis methods of serinol and serinol-derivatives are summarized. Their applications are presented as well. Meanwhile，the advantages and development trends of serinol synthesis by biological methods are given. This review provides scientific guidance for further research on synthesis and production of serinol and serinol-derivatives.

Key words: serinol, serinol-derivatives, synthesis, applications

摘要： 丝氨醇是一种重要的化学合成中间体，广泛应用于医药、化工等领域。当前丝氨醇的生产主要通过以2-硝基-1,3-丙二醇、二羟基丙酮肟等物质为基础的化学合成方法，但该方法存在高污染、高能耗、难以分离纯化等问题。与传统的化学法相比，通过氨基转移酶等物质介导的生物途径合成丝氨醇，因其绿色环保、低能耗的优势受到人们越来越多的关注。本文对丝氨醇及其衍生物的化学与生物合成方法进行了详细地阐述与分析，并介绍了这类物质在各领域的应用；同时，总结了生物法合成丝氨醇及其衍生物的优势，指出了其未来的发展方向。为进一步研究和开发丝氨醇及其衍生物的制备生产提供了科学性的指导。

关键词: 丝氨醇, 丝氨醇衍生物, 合成, 应用