Abstract:

Polyaspartic acid (PASP) gel was prepared with glycerol triglycidyl ether as the cross-linking agent. The thermal properties and viscoelasticity of this hydrogel were investigated, and the biodegradability was investigated by plate culture and zymotic fluid culture. Results showed that the glycerol triglycidyl ether crosslinked hydrogel had better heat resistance and viscoelasticity. The plate test proved that PASP hydrogel also had good biodegradability. The zymotic fluid culture proved that the type and dosage of crosslinking agent had great influence on the degradation of hydrogel. When the crosslinking agent was glycerol triglycidyl ether and the crosslinking degree was 60%, the degradation rate of gel on the ninth day was 49.3%, which was 9.2% lower than that of crosslinking agent of ethylene glycol diglycidyl ether, indicating that the network structure of glycerol triglycidyl ether was denser under the same crosslinking degree. When the cross-linking agent was glycerol triglycidyl ether and the crosslinking degree was 40%, the gel degradation rate was 59.8%, which was 17.5% higher than that when the cross-linking degree was 60%. This work laid a foundation for the practical application of polyaspartic acid hydrogel.

Key words: polyaspartic acid hydrogel, glycerol triglycidyl ether, biodegradability, zymotic fluid culture

摘要：

以丙三醇三缩水甘油醚为交联剂制备聚天冬氨酸凝胶，考察了凝胶的热性能和黏弹性，并采用平板培养和液体培养法考察了凝胶的生物降解性。结果表明：丙三醇三缩水甘油醚交联凝胶具有良好的吸水保水性，且耐热性和黏弹性更优，平板试验证明凝胶也具有良好的生物降解性，液体培养法证明交联剂的种类和用量对凝胶的降解有较大影响，交联度均为60%的凝胶，交联剂为丙三醇三缩水甘油醚时第9天降解率为49.3%，较交联剂为乙二醇二缩水甘油醚制备的凝胶低9.2%，说明在相同交联度下丙三醇三缩水甘油醚形成的网络结构更致密；交联剂均为丙三醇三缩水甘油醚时，交联度为40%的第9天降解率为59.8%，较交联度为60%的凝胶提高了17.5%，交联度增加，降解速率降低。

关键词: 聚天冬氨酸凝胶, 丙三醇三缩水甘油醚, 生物降解性, 液体培养法