Preparation and properties of silanylated polysuccinimide-loaded avermectin

doi:10.16085/j.issn.1000-6613.2021-2084

Abstract

Abstract:

In order to reduce the loss and degradation of pesticides, the nanomaterial and nanotechnologies have great potential to develop new nanoformulation. Silanylated polysuccinimide (PDSi) was prepared by the amine bond ring-opening reaction with 3-aminopropyl triethoxysilane and diaminobutane as functional monomers, which encapsulated avermectim (AVM) via self-assembly to form AVM@PDSi nanoparticles system. Compared with bare AVM, the leaves adhesion of AVM@PDSi is significantly improved with its leaf retention increased by 56.50%. Moreover, PDSi has good antioxidant activity with the maximum scavenging rate of 1,1-diphenyl-2-picrylhydrazide (DPPH) free radical being up to 41.88%. Under the same UV irradiation (E_max=365nm), the half-life of AVM (AVM@PDSi) is nearly half longer than bare AVM. Also, AVM@PDSi can intelligently control pesticide release by adjusting monomer ratio and pH, with the releasing rate for AVM@PDSi-3 being 67% after 72h and the fastest releasing at pH 9. More importantly, AVM@PDSi shows the good storage stability and retains the toxicity for insecticidal effect.

Key words: polysuccinimide, silanylated, nanomaterial, support, stability

摘要：

为了减少农药的流失和降解，采用纳米材料与技术开发新型纳米剂型具有巨大潜力。本文以3-氨丙基三乙氧基硅烷（APTES）和丁二胺（DBA）为改性单体，采用胺解开环反应制备了硅烷化聚琥珀酰亚胺（PDSi），并通过自组装方式负载阿维菌素（AVM）得到AVM@PDSi纳米体系。结果表明，相较于原药，AVM@PDSi对叶面的黏附性明显提升，叶面滞留量提高了56.50%。PDSi材料具有良好的抗氧化活性，PDSi对1，1-二苯基-2-苦基肼（DPPH）自由基的清除率最高可达41.88%。AVM@PDSi具有良好的抗紫外性能，在相同的紫外强度照射下（E_max=365nm），AVM@PDSi半衰期比原药AVM延长了近一半。AVM@PDSi具有良好的缓释性能和pH响应释放性能，在pH=9时释放最快；在pH=7时，AVM@PDSi-3在72h后累积释放量为67%。研究表明，AVM@PDSi具有良好的储存稳定性，并且保留了AVM的杀虫活性。

关键词: 聚琥珀酰亚胺, 硅烷化, 纳米材料, 载体, 稳定性

CLC Number:

TQ028.8

SU Shaochun, LIN Chengwei, ZHOU Xinhua, ZHOU Hongjun. Preparation and properties of silanylated polysuccinimide-loaded avermectin[J]. Chemical Industry and Engineering Progress, 2022, 41(8): 4481-4490.

苏少纯, 林成威, 周新华, 周红军. 硅烷化聚琥珀酰亚胺负载阿维菌素的制备与性能[J]. 化工进展, 2022, 41(8): 4481-4490.

Figures/Tables 13

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