Abstract: 2,6-diamido-3-nitrotoluene（DANT）was synthesized from 2,6-diamidotoluene，via acylation and nitration. The target compound 2,6-diamido-3-nitrotoluene was got with purity 97.6% and total yield 62%. The effects of solvent amount，reaction time and reaction temperature were investigated，and the optimal process parameters were as follows：the volume ratio of acetic anhydride and acetic acid 1∶2，reaction temperature 80℃，reaction time 2h in acylation reaction；the ratio of concentrated nitric acid and 2,6-acetamidotoluene 1.38∶1，reaction temperature 10℃ in nitration. Then the product was obtained through hydrolysis at 105℃. The product was characterized with 13C-NMR and MS.

Key words: 2,6-diamido-3-nitrotoluene, 2,6-diamidotoluene, synthesis, nitration

摘要： 以2,6-二氨基甲苯为原料，酰化反应得到2,6-二乙酰氨基甲苯，混酸硝化，水解得到2,6-二氨基-3-硝基甲苯（DANT）目标产品。纯度97.6%、总收率达62%以上。考察了溶剂用量、反应时间，反应温度等因素的影响，优化选择了各反应的较佳工艺参数。酰化反应中，乙酸酐与乙酸的体积比为 1∶2，温度80℃，反应时间2h；硝化反应中，浓硝酸与2,6-二乙酰氨基甲苯的摩尔比1.38∶1，温度为10℃。105℃回流，酸性水解，得产品。产品经13C-NMR、MS 进行了结构表征。

关键词: 2, 6-二氨基-3-硝基甲苯, 2, 6-二氨基甲苯, 合成, 硝化