Abstract: Poly-L-arginine/calcium alginate microcapsules were prepared by emulsification-gelation. The influences of different concentrations of sodium alginate and calcium chloride as well as different molecular weights of poly-L-arginine on drug loading and controlled-release of bovine haemoglobin in microcapsules were investigated. The microcapsules with medium molecular weight of poly-L-arginine had higher drug-loading amount and better controlled release behavior. The drug-loading amount of microcapsules decreased with the increase of sodium alginate concentration. As the concentration of calcium chloride increased，the drug-loading amount firstly increased and then decreased slightly，however，the release properties were not obviously affected.

Key words: emulsification-gelation, sodium alginate, poly-L-arginine, microcapsules, controlled release, emulsification-gelation, sodium alginate, poly-L-arginine, microcapsules, controlled release

摘要： 采用乳化-固化法，制备海藻酸钙/聚精氨酸微胶囊。分别考察不同聚精氨酸相对分子质量、海藻酸钠浓度、氯化钙浓度对海藻酸钙-聚精氨酸微胶囊载药量以及牛血红蛋白缓释性能的影响。实验结果表明，中相对分子质量聚精氨酸制备的海藻酸钙/聚精氨微胶囊的载药量较高并且具有更好的缓释效果。随着海藻酸钠浓度的升高，海藻酸钙/聚精氨微胶囊的载药量降低；随着氯化钙浓度的升高，海藻酸钙/聚精氨微胶囊的载药量先升高后略有降低；然而，以上因素对海藻酸钙/聚精氨微胶囊的缓释性能均无明显影响。

关键词: 乳化-固化法, 海藻酸钠, 聚精氨酸, 微胶囊, 缓释, 乳化-固化法, 海藻酸钠, 聚精氨酸, 微胶囊, 缓释