Abstract: 5-fluorouracil as template drug，2-hydroxyethylmetacrylate as backbone monomer，methacrylic acid as functional monomer，ethyleneglycol dimethacrylate as crosslinker and 2,2’-azoisobutyronitrile as initiator were used to synthesize molecularly imprinted polymer hydrogels，which were characterized with SEM，FT-IR，and DSC. The results indicated that the hydrogel surface was poreless and smooth，and in hydrogels the template drug of 5-fluorouracil interacted with monomers into solid solutions through hydrogen bonds and unreacted monomers no longer existed. Swelling tests of imprinted hydrogels showed that swelling capacity increased with the amount of 5-fluorouracil during synthesis，and swelling ability as well as swelling speed increased with increasing pH in the system. Meanwhile tests of drug loading capacity showed that the imprinted hydrogels both performed better than the non-imprinted one and MIP(functional monomer-template molar ratio 8∶1) performed better than MIP(functional monomer-template molar ratio 4∶1) with loading capacity amounting to 0.0914 mg/g.Tests on drug release behavior of the hydrogels in simulated biological fluids indicated that all the imprinted hydrogels controlled drug release better than the non-imprinting one，and hydrogels with functional monomer-template molar ratio 8∶1 exhibited the best to control the 5-fluorouracil release process. Meanwhile，release media with a high pH was unfavorable to controlled release of the imprinted hydrogel.

Key words: controlled release of drug, molecular imprinting, hydrogel, 5-fluorouracil, carrier

摘要： 以氟尿嘧啶为模板药物，以甲基丙烯酸羟乙酯为骨架单体，以甲基丙烯酸为功能单体，乙二醇二甲基丙烯酸酯为交联剂，偶氮二异丁腈为引发剂合成印迹水凝胶，并通过扫描电镜、红外光谱及差示热量扫描等测试手段对凝胶进行了表征，结果表明：制备的印迹水凝胶表面无孔、光滑，氟尿嘧啶与其中的单体通过氢键结合成了复合物，同时经处理后凝胶中已不再残留未反应的单体。印迹水凝胶的吸水溶胀性能实验结果显示其吸水溶胀性能随制备中模板药物的含量的增加而增强，同时同一凝胶的溶胀速度与溶胀率随体系pH值的升高而增强。在氟尿嘧啶溶液中测定水凝胶的药物负载量，结果显示：印迹水凝胶的药物负载能力明显强于非印迹水凝胶，同时印迹水凝胶（8∶1）对药物的负载能力强于印迹水凝胶（4∶1），药物负载量高达0.0914 mg/g。在模拟体液中测试水凝胶对药物的释放效果结果显示：印迹水凝胶对药物的缓释作用明显优于非印迹水凝胶，并且印迹水凝胶（8∶1）对药物的缓释效果优于印迹水凝胶（4∶1），对药物的释放平缓，同时，释放体系pH值的升高不利于印迹水凝胶的药物缓释效果。

关键词: 药物缓释, 分子印迹, 水凝胶, 氟尿嘧啶, 载体