Abstract: In this work，quaternary ammonium-N-（4-methyl-imidazole）Chitosan（TM-MI-CS）was prepared with chitosan，1H-imidazole-4-carbaldehyde and iodomethane，and characterized by 1H NMR，FTIR，EA，etc. The micelles of TM-MI-CS made at different pH were also studied. The results showed that TM-MI-CS could form stable spherical micelles with the size between 188 nm to 607 nm at different pH，and the size of micelles was sensitive to pH changes. The critical micelle concentration（CMC）of TM-MI-CS in water was 0.714 mg/mL.

Key words: chitosan, 1H-imidazole-4-carbaldehyde, quaternization, micelle

摘要： 以壳聚糖、4-咪唑甲醛和碘甲烷为原料，制备了季铵化-N-（4-咪唑甲基）壳聚糖（TM-MI-CS）。用1H NMR、FTIR和EA等进行表征，并考察了TM-MI-CS在不同pH值条件下胶束的形成。结果表明，TM-MI-CS在水溶液中能形成稳定的胶束，TEM图显示胶束为球形结构，其临界胶束浓度为0.714 mg/mL；不同pH值条件下制备的胶束，平均粒径为188～607 nm，胶束的粒径变化对pH值具有一定的响应性。

关键词: 壳聚糖, 4-咪唑甲醛, 季铵化, 胶束