Abstract: Through alkoxylation and catalytic hydrogenation reduction reaction，4,6-diethoxy phenylenediamine（DEDAB）was synthesized from 1,5-dichloro-2,4-dinitrobenzene（DCDNB）and the experimental conditions，such as materials ratio，reaction temperature and reaction time，were investigated. Proper experimental condition for alkoxylation reaction were found as：n(1,5-dichloro-2,4-dinitrobenzene)∶n(NaOH)∶n(anhydrous C₂H₅OH)= 1∶4∶30，room temperature，reaction time 7 h，under which the yield of 1,5-diethoxy-2,4-dinitrobenzene （DEDNB） was 96.43% based on DCDNB and the purity was 99.74% as determined by HPLC；proper catalytic hydrogenation reduction reaction conditions were found as：n(1,5-diethoxy-2,4-dinitrobenzene)∶n(anhydrous C₂H₅OH)= 1∶44，w(10% Pd/C)∶w(DEDNB)=10%，reaction temperature 110 ℃，reaction time 7 h，pressure of hydrogen 1.5 MPa，under which the yield of DEDAB was 95.42% based on DEDNB and the purity was 98.87% as determined by HPLC. The molecular structures of product and its intermediates were identified by ¹H NMR，MS and FTIR.

Key words: 1,5-dichloro-2,4-dinitrobenzene（DCDNB）, 1,5-diethoxy-2,4-dinitrobenzene （DEDNB）, 4,6-diethoxy phenylene diamine（DEDAB）, alkoxylation, catalytic hydrogenation reduction

摘要： 以1,5-二氯-2,4-二硝基苯（DCDNB）为原料，经烷氧基化和催化加氢还原反应合成4,6-二乙氧基间苯二胺（DEDAB），并探索了其影响因素。结果表明合成中间体1,5-二乙氧基-2,4-二硝基苯（DEDNB）的较佳条件为：n(DCDNB)∶n(NaOH)∶n(无水C2H5OH)=1∶4∶30，室温下反应7 h，收率96.43%，HPLC纯度99.74%；产品DEDAB的较优合成工艺条件为：n(DEDNB)∶n(无水C2H5OH)= 1∶44，w(10%Pd/C)/w(DEDNB)= 10%，反应时间7 h，反应温度110 ℃，氢气压力1.5 MPa，收率95.42%，HPLC纯度98.87%。产品及中间体结构经1H NMR、MS 和FTIR分析表征确认。

关键词: 1, 5-二氯-2, 4-二硝基苯, 1, 5-二乙氧基-2, 4-二硝基苯, 4, 6-二乙氧基间苯二胺, 烷氧基化反应, 加氢还原反应