Abstract: The development in production technology for D-lactic acid with highly optical purity was largely promoted by its application as monomer for poly(lactic acid) (PLA) high-performance materials. The application，optical purity analysis and the production technology for D-lactic acid are reviewed. Special attention was focused on the strain breeding and fermentation process. Genetic engineering showed strong competition in developing efficient strain. The progress in highly efficient strain would further promote the production of D-lactic acid with highly optical purity，high yield，short fermentation time and wide range of substrates.

摘要： 高光学纯度D-乳酸在聚乳酸高性能材料方面的应用带动了D-乳酸生产工艺研究的发展。本文综述了D-乳酸的应用、光学纯度的分析方法以及制备工艺，着重介绍了D-乳酸的生产菌种选育和D-乳酸发酵的国内外研究进展，D-乳酸基因工程菌改造也已形成一定的竞争力，并指出开发光学纯度高、产量高、转化率高，发酵周期短和底物利用范围广的D-乳酸高产菌还可进一步提升D-乳酸的制备技术。