Abstract: Calcium alginate microspheres and calcium alginate/poly-L-histidine microcapsules were prepared by emulsification. The influences of different concentrations of sodium alginate and calcium chloride on the properties of microspheres，such as appearance，particle size，drug-loading amount and controlled-release properties were investigated. The results showed that particle size was mainly determined by the concentration of sodium alginate，the distribution of microspheres and their diameters were mainly affected by the concentration of calcium chloride. Drug-loading amount decreased with the increase of the concentration of sodium alginate and calcium chloride，but the burst release of microcapsules was not obvious.

摘要： 采用乳化法制备海藻酸钙微球及海藻酸钙/聚组氨酸载药微胶囊，并考察不同海藻酸钠浓度、氯化钙浓度对微球表面形态、粒径分布、载药性能及微胶囊控制释放性能的影响。结果表明海藻酸钠浓度主要影响微球的粒径大小，氯化钙浓度主要影响微球的分散程度及粒径分布，微球载药量均随海藻酸钠浓度及氯化钙浓度的增加而减小，所制备的微胶囊均无明显的突释现象。