Abstract: The poly-L-lactic acid (PLLA) scaffold reinforced by nano-hydoxyapatite (HAP) was prepared by the thermal induced phase separation method，and the morphology，porosity，mechanical property and in vitro degradation were investigated. The scaffold had three dimensional porous structure with nano-fibrous matrices. The compressive modulus of the composite scaffold reached a maximum when the mass ratio of PLLA and HAP was 80∶20，2.15 folds as compared with that of the pure nano-PLLA scaffold. The porosity of the scaffolds was higher than 88%. The results of the in vitro degradation suggested that adding nano-HAP into the PLLA scaffold depressed the degradation effectively.

摘要： 利用热致相分离法制备了纳米羟基磷灰石增强型聚乳酸纳米复合支架，研究了该支架的微观形貌、孔隙率、力学性能和体外降解等特性。扫描电镜显示该复合支架具有纳米纤维状三维网络空间结构。聚乳酸与纳米羟基磷灰石的质量配比为80∶20时，复合支架的压缩模量最高，比纯聚乳酸纳米支架高215%。制备得到的复合支架的孔隙率都大于88％。体外降解结果表明加入纳米羟基磷灰石可有效减缓聚乳酸纳米复合支架的降解速度。