Abstract: 1,4-dipalmitoyl hydroxyroline，a skin anti-aging agent used in cosmetics was synthesized from L-hydroxyproline and palmitoyl chloride. The influence factors，such as molar ratio of raw materials，the reaction time，temperature and media of reaction were studied. The appropriate reaction conditions were as follows：volume ratio of acetone 50%，molar ratio of L-hydroxyproline to palmitoyl chloride 1∶2.5，pH 9－10，reaction temperature 15 ℃，reaction time 4 h. After separation，a white solid powder with melting point of 81－85 ℃ was obtained.

摘要： 对化妆品用皮肤抗衰老剂1,4-二棕榈酰羟脯氨酸的合成工艺进行了研究。重点对棕榈酰氯与羟脯氨酸缩合反应的摩尔比、反应时间、反应温度、反应介质、pH值等因素进行了考察。得到的适宜的反应条件为：丙酮体积分数为50%、n(羟脯氨酸)∶n(棕榈酰氯)＝1∶2.5、pH=9～10、反应温度15 ℃、反应时间4 h。产物经纯化后得到熔点为81～85 ℃的白色固体粉末。