Abstract: In this paper,we adopt the technology of patent CN 102863437 A,use Aspen Batch Process Developer modeling and simulation system,design batch process.The inherent advantages of batch processes,including their ability to produce multiple related products in the same facility,as well as their ability to handle variations in feed stocks,product specifications and market demand patterns,makes them well suited for the manufacture of low-volume,high-value products.For these reasons,batch processes are the production scheme of choice for the pharmaceutical,biotechnology,specialty chemical,consumer products and agricultural chemical industries.The production of these high value-added gyon chemicals,as opposed to bulk,commodity chemicals,today contributes a significant and growing portion of the revenue and earnings of the chemical process industries.Over the last four decades,the use of computer-based modeling and simulation tools to support process development and design has become routine in the continuous chemical industry.However,this is still not the case in the batch process industry.The main reason for this has been the unavailability of such tools for batch processes until recently.A number of these tools are available today,including BATCHES,gPROMS and Aspen Batch Process Developer.This paper describes the use of Aspen Batch Process Developer modeling and simulation system in preliminary design and optimization of production plant process of 25 tons of lurasidone hydrochloride.The production process is divided into six modules,sulfonation,ammonolysis,hydrogenation,synthesis,salify and purify.The overall design and optimization implement quality from design concept.

Key words: lurasidone hydrochloride, Aspen Batch Process Developer, process simulation, optimization design

摘要： 采取专利CN 102863437 A的工艺，设计间歇工艺过程，将Aspen Batch Process Developer软件应用于盐酸鲁拉西酮原料药车间设计的全流程模拟和优化。间歇操作具有显著的优势：生产灵活，同一设备可生产不同产品，可根据市场需要调节生产能力及变更产品。适合于小批量，高收益的精细化学品。过去的四十年里，使用计算机对化工连续化生产进行模拟和设计已经十分普及。制药工业与传统化工最大的区别是生产过程多采用间歇法操作。目前世界上应用于化工间歇生产的计算机软件有BATCHES、gPROMS和Aspen Batch Process Developer。本文所用版本为Aspen Tech V8.6，以年产25t盐酸鲁拉西酮原料药车间为例，对车间进行全流程模拟及优化。整个设计贯彻质量源于设计理念，运用元葱模型，将盐酸鲁拉西酮的生产工艺分为磺化、氨解、氢化、缩合、成盐、精烘包等6个模块。

关键词: Aspen Batch Process Developer, 制药工程, 间歇操作, 流程模拟, 优化设计