关键词: 微反应器, 微通道, 间甲基苯甲醚

Abstract:

M-methylanisole is a dye intermediate. Its traditional synthesis method controls the mixing of reactants by low temperature, and the production efficiency is low. Improving the mixing of reactants through microreactors has important research value. The synthesis process of m-methylanisole with the aid of a microreactor was systematically studied, and it was found that m-cresol and sodium hydroxide reacted quickly to form sodium m-cresol in the reaction system. The oxyalkylation reaction between sodium m-cresol and dimethyl sulfate could be enhanced with the increase of the reaction temperature, and therefore the high temperature of 60—80℃ was more beneficial for the oxyalkylation reaction to compete with the hydrolysis of dimethyl sulfate. The effects of reactant flow ratio, metering ratio, concentration and other factors on the yield of m-methylanisole were investigated, and it was found that the microreactor to ensure the rapid and uniform mixing of the two-phase reactants was crucial for the success of fast and high temperature reaction. The relatively optimized experimental results showed that the yield of m-methylanisole reached more than 99% as the molar ratio of dimethyl sulfate to m-cresol was greater than 1.05 and 30% sodium hydroxide solution was used during the reaction.

Key words: microreactor, microchannel, m-methylanisole