关键词: 纳米粒子, 表面, 牛血清白蛋白, 壳聚糖, 蛋白质

Abstract: Chitosan was grafted onto the surface of Fe3O4 magnetic nanoparticles fabricated by a chemical coprecipitation method by using (3-chloropropyl) trimethoxysilane as a coupling agent. The modified magnetic nanoparticles were characterized by infrared spectroscopy (FTIR)，X-ray diffraction (XRD)，scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA). The adsorption properties of the magnetic nano-adsorbent for BSA were investigated under different conditions，including adsorption time，pH and concentration of bovine serum albumin. The size of nanoparticles was about 20 nm，and chitosan made up 15.40% of the weight of the modified Fe3O4 magnetic nanoparticles. Compared with Fe3O4 nanoparticles，chitosan modified nanoparticles showed higher BSA adsorption capacity.

Key words: nanoparticles, surface, bovine serum albumin, chitosan, protein