关键词: 本质安全, 本质安全化设计, 热危险性, 氧化反应

Abstract: The majority of nitric acid oxidation of alcohol reactions are strong exothermic reaction and thermal runaway is easy to occur. Therefore，inherently safer design is demanded to eliminate or reduce the reaction hazards. This work demonstrated the performance of three inherently safer designs in nitric acid oxidation of 2-octyl alcohols process combined with inherent safety guidewords and the thermal safety analysis theories. Three inherently safer designs were the increase of reaction temperature advisably （Design Ⅰ），lower the liquid immiscibility （Design Ⅱ） and temperature - charging interlock （Design Ⅲ）. The assessment model of inherent safety level was built based on the inherent safety evaluation indicators and their assignment modes，and the rationality of three designs was validated by the assessment model. The results showed that the inherent safety degree of the process was improved by the three inherently safer designs by about 11.7%，12.8% and 10.7%，respectively. Meanwhile，three designs were based on “minimize” and “moderation” principles in improving the inherent safety degree of process.

Key words: inherent safety, inherently safer design, thermal hazard, oxidation reaction