关键词: 微通道反应器, 环己酮, ε-己内酯, Baeyer-Villiger氧化

Abstract: Peracetic acid was prepared as an oxidant from acetic anhydride and H2O2 firstly，and then ε-caprolactone was synthesized by Baeyer-Villiger oxidization of cyclohexanone in a continuous flow micro-channel reactor. The effects of reactants molar ratio，reaction temperature and residence time on reactant conversion and product yield were investigated for both preparation of peracetic acid and synthesis of ε-caprolactone，and the process conditions were optimized. Under conditions of n(acetic anhydride) ∶n(H2O2) = 1.2∶1，reaction temperature at 70℃，residence time of 115s，conversion of H2O2 reached 88.9% and yield of peracetic acid reached 86.7%. Under conditions of n(peracetic acid) ∶n(cyclohexanone) = 1.1∶1，reaction temperature at 90℃，residence time of 90s，conversion of cyclohexanone reached 96.2% and yield of ε-caprolactone reached 80.9%. Comparing with the traditional batch reaction process，the selectivities and yields of target products in this continuous micro-channel reaction process were increased with shortened reaction time and lessened raw material consumption，and process continuity ensured higher operation safety.

Key words: micro-channel reactor, cyclohexanone, ε-caprolactone, Baeyer-Villiger oxidation