Abstract: Abstract：The application of ASPEN’s PIMS for Wuhan Branch Company, SINOPEC is introduced in this article. The optimization and analysis of three cases, including the selection of reforming feed, the flow direction of vacuum residue and the maximum processable sulfur content of crude oil are implemented by PIMS. The results showed that (1) The benefit of purchased reforming feed changes with the change of aromatic hydrocarbon yield; (2) The benefit of selling vacuum residue can be realized only at a higher price; (3) The maximum processable sulfur content of crude oil for the present Wuhan branch company equipment is 0.85%.