化工进展

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葡萄糖二酸的生物炼制及应用研究进展

余作龙,苗江月,曹 飞,周佳栋,朱 璇,王月霞,韦 萍   

  1. 南京工业大学生物与制药工程学院,江苏 南京 210009
  • 出版日期:2011-11-05 发布日期:2011-11-05

Research progress in preparation and application of bio-refined D-glucaric acid

YU Zuolong,MIAO Jiangyue,CAO Fei,ZHOU Jiadong,ZHU Xuan,WANG Yuexia,WEI Ping   

  1. College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,Jiangsu,China
  • Online:2011-11-05 Published:2011-11-05

摘要:

葡萄糖二酸是含有多羟基的二元酸,广泛来源于葡萄糖基物质,可用于可降解聚合物、药物和食品等产品的制备。本文介绍了硝酸氧化、TEMPO氧化等化学法和生物法制备葡萄糖二酸的原理和方法,并综述了其在抗癌及显像剂药物、聚合物等方面的应用。

Abstract:

D-glucaric acid is a dicarboxylic acid containing polyhydroxy. It can be obtained from many glucose-based substances and be used to prepare products of biodegradable polymerspharmaceuticals and food. In this reviewwe try to describe the principles and preparation methods of D-glucaric acid in both chemicalnitric acid oxidation and TEMPO oxidationand biological fieldsand review its applications in both pharmaceuticalsanticancer drugs and imaging agentsand polymers.

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