化工进展

• 材料科学与技术 • 上一篇    下一篇

均匀设计法优化β-环糊精微球的制备工艺

苏秀霞，支娟娟，李仲谨，杨 威，赵钤妃   

  1. 陕西科技大学化学与化工学院，教育部轻化工助剂化学与技术重点实验室，陕西 西安 710021
  • 出版日期:2011-08-05 发布日期:2011-08-05

Optimal preparation of β-cyclodextrin microsphere using uniform design

SU Xiuxia，ZHI Juanjuan，LI Zhongjin，YANG Wei，ZHAO Qianfei   

  1. Key Laboratory of Auxiliaries Chemistry & Technology for Chemical Industry，Ministry of Education，School of Chemistry and Chemical Engineering，Shaanxi University of Science & Technology，Xi’an 710021，Shaanxi，China
  • Online:2011-08-05 Published:2011-08-05

被引次数

8

摘要：

为了优化β-环糊精微球的制备工艺，采用U13*（134）均匀设计对合成工艺优化，得出最佳合成工艺为反应温度80 ℃，反应时间4 h，交联剂的用量8 g，搅拌速度1000 r/min。影响微球粒径的因素：搅拌速度>反应温度。影响产量的因素：交联剂的用量>反应时间。最佳合成工艺下的微球表面圆整，具有较好的热稳定性。

Abstract:

The preparation of β-cyclodextrin microspheres was optimized by using U13*（134）uniform design. The result showed that the optimμm reaction temperature was 80 ℃，reaction time was 4 h，the amount of crosslinker was 8 g and stirring speed was 1000 r/min. The factors affecting microsphere size were stirring speed，and reaction temperature. The factors affecting yield were crosslinking agent，and reaction time. The surface of those β-CD microspheres under optimal conditions was smooth and had good thermal stability.

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