化工进展

• 材料科学与技术 • 上一篇    下一篇

均匀设计法优化β-环糊精微球的制备工艺

苏秀霞,支娟娟,李仲谨,杨 威,赵钤妃   

  1. 陕西科技大学化学与化工学院,教育部轻化工助剂化学与技术重点实验室,陕西 西安 710021
  • 出版日期:2011-08-05 发布日期:2011-08-05

Optimal preparation of β-cyclodextrin microsphere using uniform design

SU Xiuxia,ZHI Juanjuan,LI Zhongjin,YANG Wei,ZHAO Qianfei   

  1. Key Laboratory of Auxiliaries Chemistry & Technology for Chemical Industry,Ministry of Education,School of Chemistry and Chemical Engineering,Shaanxi University of Science & Technology,Xi’an 710021,Shaanxi,China
  • Online:2011-08-05 Published:2011-08-05

摘要:

为了优化β-环糊精微球的制备工艺,采用U13*134)均匀设计对合成工艺优化,得出最佳合成工艺为反应温度80 ,反应时间4 h,交联剂的用量8 g,搅拌速度1000 r/min。影响微球粒径的因素:搅拌速度>反应温度。影响产量的因素:交联剂的用量>反应时间。最佳合成工艺下的微球表面圆整,具有较好的热稳定性。

Abstract:

The preparation of β-cyclodextrin microspheres was optimized by using U13*134uniform design. The result showed that the optimμm reaction temperature was 80 reaction time was 4 hthe amount of crosslinker was 8 g and stirring speed was 1000 r/min. The factors affecting microsphere size were stirring speedand reaction temperature. The factors affecting yield were crosslinking agentand reaction time. The surface of those β-CD microspheres under optimal conditions was smooth and had good thermal stability.

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