相分离制备聚己内酯纳米纤维支架的工艺探讨

化工进展

相分离制备聚己内酯纳米纤维支架的工艺探讨

刘淑琼，肖秀峰，刘榕芳，钟章裕，焦简金

福建师范大学福建省高分子重点实验室，福建师范大学化学与材料学院，福建福州 350007

出版日期:2011-05-05 发布日期:2011-05-05

Fabrication of polycaprolactone nanofibrous scaffolds by thermally induced phase separation

LIU Shuqiong，XIAO Xiufeng，LIU Rongfang，ZHONG Zhangyu，JIAO Jianjin

Fujian Key Laboratory for Polymer Materials，College of Chemistry and Materials Science，Fujian Normal University，Fuzhou 350007，Fujian，China

Online:2011-05-05 Published:2011-05-05

摘要/Abstract

摘要：

以二氧六环/水为溶剂体系采用相分离方法首次成功制备了高孔隙率、具有纳米纤维状结构的聚己内酯（PCL）支架，并且支架是以球体为结构单元的基体。文中主要探讨了陈化温度和溶剂比例对于球状纳米纤维结构支架形成的影响，太低（—40 ℃）或太高的陈化温度（≥8 ℃）均不利于PCL纳米纤维结构的出现，只有适宜的实验温度才可以得到纳米纤维球状基体。同样，非溶剂比例越大越不利于纳米纤维球状基体的形成。

Abstract:

Polycaprolactone（PCL）three-dimensional（3D）scaffold with spherulite and nanofibrous was first fabricated by thermally induced phase separation from a ternary PCL/dioxane/water system. The effects of aging temperature，ratio of dioxane and water on the morphology of nanofibrous scaffolds were investigated. The results showed that aging temperature played a crucial role in forming the unique nanofibrous structure. A higher gelation temperature or a higher content of water in the mixed solvent system was not favorable for the spherulite -like morphology of scaffold. Coalescence of nanofibers occurred，even spherulite -like structure disappeared at a gelation temperatures higher than 8℃ or lower than －40℃ and at a proportion of water exceeding 12%.

刘淑琼，肖秀峰，刘榕芳，钟章裕，焦简金. 相分离制备聚己内酯纳米纤维支架的工艺探讨 [J]. 化工进展.

LIU Shuqiong，XIAO Xiufeng，LIU Rongfang，ZHONG Zhangyu，JIAO Jianjin. Fabrication of polycaprolactone nanofibrous scaffolds by thermally induced phase separation[J]. Chemical Industry and Engineering Progree.